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TranscriptomicsThe tumor antigen PRAME is a substrate recognition subunit of a Cul2-based ubiquitin ligase and is associated with active NFY promoters
The human tumor antigen PRAME (Preferentially expressed antigen of melanoma) is frequently overexpressed in tumors. High PRAME levels correlate with poor clinical outcome of several cancers, but the mechanisms by which PRAME could be involved in tumorigenesis remain largely elusive. We applied prote...
ORGANISM(S): Homo sapiens 
2011-07-29 | E-GEOD-26439 | biostudies-arrayexpress
GenomicsPRAMEL7 and CUL2 decrease NuRD stability to establish ground-state pluripotency
PRAMEL7 and CUL2 decrease NuRD stability to establish ground-state pluripotency
PRJNA889810 | ENA
UnknownCUL2 overexpression driven by CUL2/E2F1/miR-424 regulatory loop promotes HPV16 E7 induced cervical carcinogenesis.
Not available
S-EPMC5058775 | biostudies-literature
ProteomicsPramel7-Cul2 axis establishes ground-state gene expression in embryonic stem cells
Pluripotency is established in E4.5 preimplantation epiblast, the founder populations of the adult embryo. The establishment of in vitro models that closely resemble ground-state pluripotency represents an important opportunity to study early embryo development. Pramel7, a protein highly expressed i...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-08 | PXD032184 | Pride
Pluripotency Embryonic stem cells Pramel7 Proteasome Cullin 2 
TranscriptomicsPRAMEL7 and CUL2 decrease NuRD stability to establish ground-state pluripotency
Pluripotency is established in E4.5 preimplantation epiblast. Embryonic stem cells (ESCs) represent the immortalization of pluripotency, however, they only partially resemble the gene expression signature of developmental ground-state. Induced PRAMEL7 expression, a protein highly expressed in the IC...
ORGANISM(S): Mus musculus 
2024-01-08 | GSE215339 | GEO
Genomics
Cul2 controls beige adipocyte biogenesis
PRJNA758917 | ENA
UnknownCrystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex.
Not available
S-EPMC5462531 | biostudies-literature
UnknownExpression and purification of functional recombinant CUL2•RBX1 from E. coli.
Not available
S-EPMC8160325 | biostudies-literature
UnknownMicroRNA-154-5p regulates the HPV16 E7-pRb pathway in Cervical Carcinogenesis by targeting CUL2.
Not available
S-EPMC7391205 | biostudies-literature
UnknownPRAMEL7 and CUL2 decrease NuRD stability to establish ground-state pluripotency.
Not available
S-EPMC10933316 | biostudies-literature
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