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ProteomicsPramel7-Cul2 axis establishes ground-state gene expression in embryonic stem cells
Pluripotency is established in E4.5 preimplantation epiblast, the founder populations of the adult embryo. The establishment of in vitro models that closely resemble ground-state pluripotency represents an important opportunity to study early embryo development. Pramel7, a protein highly expressed i...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-08 | PXD032184 | Pride
Pluripotency Embryonic stem cells Pramel7 Proteasome Cullin 2 
GenomicsPRAMEL7 and CUL2 decrease NuRD stability to establish ground-state pluripotency
PRAMEL7 and CUL2 decrease NuRD stability to establish ground-state pluripotency
PRJNA889810 | ENA
UnknownPRAMEL7 and CUL2 decrease NuRD stability to establish ground-state pluripotency.
Not available
S-EPMC10933316 | biostudies-literature
TranscriptomicsPRAMEL7 and CUL2 decrease NuRD stability to establish ground-state pluripotency
Pluripotency is established in E4.5 preimplantation epiblast. Embryonic stem cells (ESCs) represent the immortalization of pluripotency, however, they only partially resemble the gene expression signature of developmental ground-state. Induced PRAMEL7 expression, a protein highly expressed in the IC...
ORGANISM(S): Mus musculus 
2024-01-08 | GSE215339 | GEO
Genomics
Pramel7 mediates naïve pluripotency through proteasomal-epigenetic combined pathways
PRJEB12665 | ENA
UnknownPRAMEL7 and CUL2 decrease NuRD stability to establish ground-state pluripotency
Not available
S-SCDT-10_1038-S44319-024-00083-Z | biostudies-other
TranscriptomicsThe disruption of CtBP regulates DUX-dependent and -independent genetic program for the 2-cell-like state in murine embryonic stem cells [RNA-seq and RRBS]
After fertilization, maternally deposited mRNA is cleared, and de novo mRNA is transcribed from the zygotic genome through zygotic genome activation (ZGA), which is called maternal-to-zygotic transition (MZT) occurring in the mouse at 2-cell (2C) stage. 2C-like cells (2CLCs) marked by MERVL expressi...
ORGANISM(S): Mus musculus 
2024-05-27 | GSE253944 | GEO
UnknownExpression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.
Not available
S-EPMC2409313 | biostudies-literature
TranscriptomicsLineage-specific enhancer insertions regulate Prdm14 to drive the rapid transition from naïve to formative pluripotency in rodents
The network of transcription factors is dynamically reorganized during the transition from naïve to formative pluripotency. In mice, Prdm14 is expressed in naïve pluripotent cells but rapidly downregulated upon exit from the naïve state. In contrast, PRDM14 expression persists throughout pluripotenc...
ORGANISM(S): Mus musculus 
2025-11-20 | GSE309484 | GEO
GenomicsThe disruption of CtBP regulates DUX-dependent and -independent genetic program for the 2-cell-like state in murine embryonic stem cells [RNA-seq and RRBS]
The disruption of CtBP regulates DUX-dependent and -independent genetic program for the 2-cell-like state in murine embryonic stem cells [RNA-seq and RRBS]
PRJNA1067733 | ENA
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