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UnknownRat hormone sensitive lipase inhibition by cyclipostins and their analogs.
Not available
S-EPMC4340684 | biostudies-literature
UnknownCyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis.
Not available
S-EPMC5603573 | biostudies-literature
UnknownCyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus.
Not available
S-EPMC11613490 | biostudies-literature
UnknownSynthesis and kinetic evaluation of cyclophostin and cyclipostins phosphonate analogs as selective and potent inhibitors of microbial lipases.
Not available
S-EPMC3518039 | biostudies-literature
ProteomicsCyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by Erm(41) in Mycobacterium abscessus
Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections, particularly in individuals with underlying conditions, such as cystic fibrosis or chronic obstructive pulmonary disease. Macrolides, including clarithromycin (CLR) and azithromycin (AZM), represent the current corn...
ORGANISM(S): Mycobacterium abscessus Bacteria 
2024-12-05 | PXD055560 | Pride
Lc-msms Resistance Macrolide Synergy testing Erm(41) Drug susceptibility Mycobacterium abscessus 
ProteomicsCyclipostins and Cyclophostin analogs impair growth of Mycobacterium abscessus by inhibiting enzymes involved in many physiological processes
Mycobacterium abscessus is nowadays under the spotlight of the scientific community. This pathogenic mycobacteria is indeed responsible for a wide spectrum of infections involving mostly pulmonary infections in patients with cystic fibrosis. M. abscessus is intrinsically resistant to a broad range o...
ORGANISM(S): Mycobacterium abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543) 
2019-10-08 | PXD014255 | Pride
Anti-mycobacterial agents Total synthesis  drug susceptibility  activity based-protein profiling  proteomics analysis 
ProteomicsDirect capture, inhibition and crystal structure of HsaD (Rv3569c) from M. tuberculosis by Cycliphostin & Cyclipostins analogs
Tuberculosis (TB) which is one of the deadliest infectious disease worldwide, is caused by the inhalation of the pathogenic bacteria Mycobacterium tuberculosis. Since many years now, the emergence of multiple (MDR), extensively (XDR) and totally (TDR) drug resistant strains amplifies the incidences ...
ORGANISM(S): Mycobacterium tuberculosis H37Rv Bacteria 
2022-09-20 | PXD034921 | Pride
Lc-msms  drug susceptibility  activity based-protein profiling  proteomic analysis  biochemical characterization  3d structure 
ProteomicsMapping of mycobacterial lipolytic enzymes involved in triacylglycerol accumulation as intrabacterial lipid inclusions using multi-target inhibitor-like affinity-based probes
Mycobacteria are known for their unique and complex cell wall architecture, characterized by distinct lipid-rich outer layers, making lipid metabolism a central point of their physiological processes. One crucial aspect of all mycobacteria is their ability to metabolize host lipids and to accumulate...
ORGANISM(S): Mycobacterium abscessus 
2025-05-12 | PXD048770 | Pride
Mycobacterium Lc_msms Activity-based protein profiling  multitarget inhibitor-like affinity-based probes  lipid metabolism  cyclipostins & cyclophostin  oxadiazolone 
ProteomicsThe polyamino-isoprenyl enhancer NV716 potentializes the antibacterial activity of two families of multitarget inhibitors against the ESKAPEE bacterium Enterobacter cloacae, Part1bis (Enterobacter cloacae)
The spread of antimicrobial resistance (AMR), coupled with the decline in antibiotic development, has become a major public health concern. Recent studies estimate that around 700,000 people die each year from infections caused by multidrug-resistant (MDR) bacteria. This led the WHO to publish the E...
ORGANISM(S): Enterobacter cloacae 
2025-02-27 | PXD053955 | Pride
Gram-negative bacteria  antibiotic resistance  drug enhancers  oxadiazolone derivatives  cyclipostins & cyclophostin analogs  activity based-protein profiling 
ProteomicsThe polyamino-isoprenyl enhancer NV716 potentializes the antibacterial activity of two families of multitarget inhibitors against the ESKAPEE bacterium Enterobacter cloacae – Part2 (Pseudomonas. aeruginosa)
The spread of antimicrobial resistance (AMR), coupled with the decline in antibiotic development, has become a major public health concern. Recent studies estimate that around 700,000 people die each year from infections caused by multidrug-resistant (MDR) bacteria. This led the WHO to publish the ...
ORGANISM(S): Pseudomonas aeruginosa BWHPSA046 
2025-02-27 | PXD052024 | Pride
Gram-negative bacteria  antibiotic resistance  drug enhancers  oxadiazolone derivatives  cyclipostins & cyclophostin analogs  activity based-protein profiling Lc-msms 
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