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MetabolomicsEffects of altering serine metabolic pathways and ROS levels on macrolide resistant strains of Streptococcus suis

In this study, we proposed to obtain the differential metabolic pathways before and after the development of macrolide resistance in Streptococcus suis strain ATCC700494 and the macrolide resistant strain obtained by pre-laboratory induction of strain ATCC700794 as the test strains by non-targete...

2022-07-12 | MTBLS4618 | MetaboLights
TranscriptomicsTranscriptional profile in macrolide susceptible and resistant Campylobacter jejuni
Campylobacter jejuni is a major zoonotic pathogen transmitted to humans via the food chain. C. jejuni is prevalent in chickens, a natural reservoir for this pathogenic organism. Due to the importance of macrolide antibiotics in clinical therapy of human campylobacteriosis, development of macrolide r...
ORGANISM(S): Campylobacter jejuni 
2011-11-02 | E-GEOD-33330 | biostudies-arrayexpress
ProteomicsCyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by Erm(41) in Mycobacterium abscessus
Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections, particularly in individuals with underlying conditions, such as cystic fibrosis or chronic obstructive pulmonary disease. Macrolides, including clarithromycin (CLR) and azithromycin (AZM), represent the current corn...
ORGANISM(S): Mycobacterium abscessus Bacteria 
2024-12-05 | PXD055560 | Pride
Lc-msms Resistance Macrolide Synergy testing Erm(41) Drug susceptibility Mycobacterium abscessus 
TranscriptomicsThe general mode of translation inhibition by macrolide antibiotics
Macrolides are clinically important antibiotics thought to inhibit bacterial growth by impeding the passage of newly synthesized polypeptides through the nascent peptide exit tunnel of the bacterial ribosome. Recent data challenged this view by showing that macrolide antibiotics can differentially a...
ORGANISM(S): Escherichia coli BW25113 
2014-11-03 | E-GEOD-61619 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile in the macrolide resistant C. jejuni strains selected from 81-176
Campylobacter, a major foodborne pathogen, is increasingly resistant to macrolide antibibotics. previous findings suggeted that development of macrolide resistance in campylobacter requires a multi-step process, but the molecular mechanisms involved in the process are not known. In our study, multip...
ORGANISM(S): Campylobacter 
2010-12-28 | E-GEOD-17899 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile in low to high-level macrolide resistant C. jejuni strain selected from NCTC 11168
Campylobacter, a major foodborne pathogen, is increasingly resistant to macrolide antibibotics. Previous findings suggeted that development of macrolide resistance in campylobacter requires a multi-step process, but the molecular mechanisms involved in the process are not known. In our study, multip...
ORGANISM(S): Campylobacter jejuni 
2010-12-28 | E-GEOD-17881 | biostudies-arrayexpress
GenomicsMacrolide Resistant Streptococcus pyogenes
Unrevealing macrolide resistance among Streptococcus pyogenes. A 21-year study.
PRJEB38407 | ENA
TranscriptomicsTranscriptional profiles of Campylobacter jejuni macrolide resistant strain JL272 to 4mg/L erythromycin treatment
Erythromycin is the drug of choice to treat campylobacteriosis, but resistance to this antibiotic is rising. The adaptive mechanisms employed by Campylobacter jejuni to erythromycin treatment remain unknown. The aim of this study is to determine the molecular basis underlying CampylobacterM-bM-^@M-^...
ORGANISM(S): Campylobacter jejuni 
2013-10-10 | E-GEOD-43025 | biostudies-arrayexpress
ProteomicsQuantitative proteomics analysis of Mycoplasma pneumoniae identifies potential macrolide resistance determinants
Mycoplasma pneumoniae is one of the leading causes of community-acquired pneumonia in children and adolescents. Because of the wide application of macrolides in clinical treatment, macrolide-resistant M. pneumoniae strains have become increasingly common worldwide. However, the molecular mechanisms ...
ORGANISM(S): Mycoplasma pneumoniae 
2021-02-25 | PXD022220 | Pride
Drug resistance Mycoplasma pneumoniae Quantitative proteomic technique Differentially expressed proteins Whole proteomes 
TranscriptomicsSequence selectivity of macrolide-induced translational regulation
We sequenced a total of 12 cDNA libararies derived from fragmented total mRNA and ribosome protected mRNAs from azithromycin-treated and -untreated S. aureus samples. The data represented 2 independent biological replicates. Examination of the impact of azithromycin on global translatome, mRNA abund...
ORGANISM(S): Staphylococcus aureus subsp. aureus NCTC 8325 
2014-11-03 | E-GEOD-57175 | biostudies-arrayexpress
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