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ProteomicsPervasive aggregation and depletion of host and viral proteins in response to cysteine-reactive electrophilic compounds
isoTOP-ABPP performed for a small library of cysteine-reactive compounds to assess cysteine ligandability of viral and host proteins towards these compounds.
ORGANISM(S): Homo sapiens (Human) 
2024-10-24 | PXD046278 | Pride
Isotop-abpp  sars-cov-2  cysteine-reactive compounds  proteostasis  orbitrap eclipse: sp3  faims 
ProteomicsPervasive aggregation and depletion of host and viral proteins in response to cysteine-reactive electrophilic compounds
Effects to protein homeostasis processes upon treatment with cysteine-reactive covalent small molecules in viral and host proteins
ORGANISM(S): Homo sapiens (Human) 
2024-10-24 | PXD046393 | Pride
Sars-cov-2 Covalent compounds Protein degradation Cysteine-reactive elecrophiles Aggregation 
ProteomicsAccelerating multiplexed profiling of protein-ligand interactions: high-throughput plate-based reactive cysteine profiling with minimal input
Chemoproteomics investigates small molecule-protein interactions and has made significant progress in recent years. Despite its vast potential, the proteome-wide profiling of reactive cysteine ligandability remains a formidable task to adapt for high throughput applications. This is primarily due to...
ORGANISM(S): Homo sapiens (Human) 
2023-12-24 | PXD044402 | Pride
Reactive cysteine Abpp Chemoproteomics High throughput Tmt 
ProteomicsRobust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics - 80 compound screen (HEK293T and Jurkat)
In this manuscript we describe our work on the development of a label-free chemoproteomics screening platform for cysteine reactive covalent fragments on a 96 well plate format. Within this workflow, we profile cysteine reactive fragments by competition with the hyper-reactive iodoacetamide desthiob...
ORGANISM(S): Homo sapiens (Human) 
2024-11-18 | PXD054127 | Pride
Chemoproteomics Data independant acquisition Label-free qauntification 
UnknownPervasive aggregation and depletion of host and viral proteins in response to cysteine-reactive electrophilic compounds.
Not available
S-EPMC10680658 | biostudies-literature
ProteomicsRobust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics - Library Build, concentration response, structure activity relationships and in-cell treatment
In this manuscript we describe our work on the development of a label-free chemoproteomics screening platform for cysteine reactive covalent fragments on a 96 well plate format. Within this workflow, we profile cysteine reactive fragments by competition with the hyper-reactive iodoacetamide desthiob...
ORGANISM(S): Homo sapiens (Human) 
2024-11-18 | PXD054145 | Pride
Chemoproteomics. lavel-free quantification Data independant acquisition 
UnknownDifferential modulation of polycystin-2 gain-of-function channels by cysteine-reactive compounds, amphiphilic substances, and S4-S5 linker mutations.
Not available
S-EPMC12597267 | biostudies-literature
ProteomicsCysteine-reactive electrophilic compounds remodel the proteome by modulating cellular proteostasis processes
proteomics experiments performed for the elucidation of compound induced PDIA6 interactions by AP-MS and label free quantifiaction experiments to assess compound dependent UPR activation
ORGANISM(S): Homo sapiens (Human) 
2024-10-24 | PXD053865 | Pride
Sars-cov-2  cysteine-reactive compounds  proteostasis  orbitrap eclipse: sp3  faims 
ProteomicsChemoselective umpolung of thiols to episulfoniums for cysteine bioconjugation
Modification of native cysteine is an important tool in protein research and relies on fast and chemoselective reactions under bioambient conditions. Nucleophilic cysteine can be functionalized with electrophiles, such as maleimides, that carry specific chemical groups, depending on the desired appl...
ORGANISM(S): Escherichia Coli 
2023-12-20 | PXD038723 | JPOST Repository
TranscriptomicsThe global expression profile of Bacillus subtilis to the toxic carbonyls methylglyoxal (MG) and formaldehyde (FA)
Abstract of associated menuscript; Quinones and alpha,beta-unsaturated carbonyls are naturally occurring electrophiles that target cysteine residues via thiol-(S)-alkylation. We analyzed the global expression profile of Bacillus subtilis to the toxic carbonyls methylglyoxal (MG) and formaldehyde (FA...
ORGANISM(S): Bacillus subtilis 
2010-05-15 | E-GEOD-13925 | biostudies-arrayexpress
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