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MetabolomicsMetabolomics highlights reduced glutamate and acetylcarnitine in the amniotic fluid of cytomegalovirus-infected pregnant women

Cytomegalovirus (CMV) is a ubiquitous infectious agent that causes significant morbidity in immunosuppressed hosts and is the most common cause of neonatal congenital deafness.An infection acquired during pregnancy can be vertically transmitted to the fetus and cause permanent sequelae in the new...

2025-09-12 | MTBLS12415 | MetaboLights
TranscriptomicsTranscription profiling of human fetal gammadelta T cells from that cytomegalovirus (CMV) positive or negative
Response of fetal gammadelta T cells towards infection with human cytomegalovirus (CMV)
ORGANISM(S): Homo sapiens 
2009-12-12 | E-MEXP-2055 | biostudies-arrayexpress
TranscriptomicsHigh-resolution profiling and analysis of viral and host small RNAs during human cytomegalovirus infection
Small RNA deep sequencing analysis was conducted on primary human fibroblasts infected with human cytomegalovirus (HCMV). HCMV-encoded miRNAs accumulated to ~20% of the total smRNA population at late stages of infection, and our analysis led to improvements in viral miRNA annotations and identificat...
ORGANISM(S): Homo sapiens 
2011-11-10 | E-GEOD-33584 | biostudies-arrayexpress
TranscriptomicsCMV infection induces a rapid and sustained change in the expression of Natural Killer Cell Receptors on CD8+ T Cells
The CD8+ T cell compartment of human cytomegalovirus (CMV) seropositive individuals characteristically contains a high proportion of cells that expresses Natural Killer Cell Receptors (NKR) which may contribute to the surveillance of virus-infected cells. To test if this enhanced expression is a dir...
ORGANISM(S): Homo sapiens 
2008-08-28 | E-GEOD-12589 | biostudies-arrayexpress
MetabolomicsHuman Cytomegalovirus pUL37x1 is Important to Remodeling of Host Lipid Metabolism
Human cytomegalovirus (HCMV) replication requires host metabolism. Infection alters the activity in multiple metabolic pathways, including increasing fatty acid elongation and lipid synthesis. The virus-host interactions regulating the metabolic changes associated with replication are essential to i...
2020-06-26 | MTBLS1073 | MetaboLights
TranscriptomicsSmall RNAs from Arabidopsis plants infected with CMV-?2b
We focused our analyses on the description of viral (CMV-?2b) and, based on genetic and molecular evidence, classified them and discussed their relevance in antiviral defense. Small RNAs from Arabidopsis plants from different genetic backgrounds infected with (CMV-?2b) were sequenced before or after...
ORGANISM(S): Arabidopsis thaliana 
2012-03-01 | E-GEOD-27477 | biostudies-arrayexpress
TranscriptomicsHost cell gene expression late during cytomegalovirus infection
Human fibroblast monolayers plated at a density of 3 x 104 cells/cm2 in 850 cm2 roller bottles were infected at confluency (day 5 post-seeding) with purified virions of human cytomegalovirus (CMV) strain AD169varATCC (AD) or the AD169 US27/US28 deletion mutant virus RV101 (RV) at a multiplicity of i...
ORGANISM(S): Homo sapiens 
2005-08-25 | E-GEOD-3194 | biostudies-arrayexpress
TranscriptomicsIdentification of MicroRNAs and Their Targets in Tomato Infected with Cucumber Mosaic Virus
We constructed two independent small RNA libraries from leaves of mock and Cucumber mosaic virus (CMV) infected tomatoes, respectively, and sequenced with a high-throughput Illumina Solexa system. Based on sequence analysis and hairpin structure prediction, a total of 50 known miRNAs (32 families) a...
ORGANISM(S): Solanum lycopersicum 
2014-10-20 | E-GEOD-56974 | biostudies-arrayexpress
TranscriptomicsRNA-Induced Silencing Complex-associated RNA in MRC-5 cells transfected with hcmv-miR-UL22A-5p
Investigation of mRNA targets of the human cytomegalovirus miRNA UL22A-5p One 4-plex chip was hybridized with cDNA originating from either total RNA or from AGO2-associated RNA (i.e. RISC-associated RNA) from fibroblasts transfected 48 hours earlier with hcmv-miR-UL22A-5p mimic or with a negative co...
ORGANISM(S): Homo sapiens 
2015-04-08 | E-GEOD-64503 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fibroblast monolayers infected at confluency (day 5 post-seeding) with purified virions of human cytomegalovirus (CMV) strains
Human fibroblast monolayers plated at a density of 3 x 104 cells/cm2 in 850 cm2 roller bottles were infected at confluency (day 5 post-seeding) with purified virions of human cytomegalovirus (CMV) strain AD169varATCC (AD) or the AD169 US27/US28 deletion mutant virus RV101 (RV) at a multiplicity of i...
ORGANISM(S): Homo sapiens 
2005-08-23 | E-SMDB-2658 | biostudies-arrayexpress
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