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TranscriptomicsThe DDR complex facilitates the genome-wide association of RNA Polymerase V to promoters and evolutionarily young transposons
The plant-specific DNA-dependent RNA polymerase V (Pol V) evolved from Pol II to function in an RNA-directed DNA methylation pathway. Here, we have identified targets of Pol V in Arabidopsis thaliana on a genome-wide scale using ChIP-seq of NRPE1, the largest catalytic subunit of Pol V. We found tha...
ORGANISM(S): Arabidopsis thaliana 
2012-08-05 | E-GEOD-39247 | biostudies-arrayexpress
TranscriptomicsAltered levels of MOF and decreased levels of H4K16ac correlate with a defective DNA damage response (DDR).
Full title: Altered levels of MOF (member of MYST family histone acetyl transferase) and decreased levels of H4K16ac correlate with a defective DNA damage response (DDR). The human MOF gene encodes a protein that specifically acetylates histone H4 at lysine 16 (H4K16ac). Here we show that altered le...
ORGANISM(S): Homo sapiens 
2010-03-23 | E-GEOD-20193 | biostudies-arrayexpress
ProteomicsCryoEM Structures of Arabidopsis DDR Complexes Involved in RNA-directed DNA Methylation
Chemical cross-linking coupled to mass spectrometry was used to study the A. thaliana DDR complex consisting of DMS3, RMD1 and a peptide from the interaction region of DRD1. Cross-linking was performed using different cross-linking chemistries: disuccinimidyl suberate (DSS) and a combination of adip...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-07-15 | PXD013470 | Pride
Chemical cross-linking  dss  adh  dmtmm  structural proteomics  ddr complex 
UnknownRegulatory mechanism of a heat-activated retrotransposon by DDR complex in Arabidopsis thaliana.
Not available
S-EPMC9811314 | biostudies-literature
TranscriptomicsKDM6 Inhibition induces DNA Damage Response (DDR) during ESC Differentiation but not during self-renewal.
The discovery of the first histone demethylase in 2004 (LSD1/KDM1) opened new avenues for the understanding of how histone methylation impacts cellular functions. A great number of histone demethylases have been identified since, which are potentially linked to gene regulation as well as to stem cel...
ORGANISM(S): Mus musculus 
2016-03-11 | E-GEOD-49886 | biostudies-arrayexpress
UnknownCryoEM structures of Arabidopsis DDR complexes involved in RNA-directed DNA methylation.
Not available
S-EPMC6718625 | biostudies-literature
GenomicsMLL1 is essential for the senescence-associated secretory phenotype
This SuperSeries is composed of the SubSeries listed below. Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory respon...
ORGANISM(S): Homo sapiens 
2016-02-22 | E-GEOD-78142 | biostudies-arrayexpress
GenomicsMLL1 is essential for the senescence-associated secretory phenotype [ChIP-Seq]
Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory response prominently includes an array of cytokines known as the se...
ORGANISM(S): Homo sapiens 
2016-02-23 | E-GEOD-78141 | biostudies-arrayexpress
TranscriptomicsDNA Damage Response and Inflammatory Signaling Limit the MLL-ENL-induced Leukemogenesis in vivo
Activation of the MLL-ENL-ERtm oncogene initiates aberrant proliferation of myeloid progenitors. Here, we show induction of a fail-safe mechanism mediated by the DNA damage response (DDR) machinery that results in activation of the ATR/ATM-Chk1/Chk2-p53/p21 checkpoint and cellular senescence at earl...
ORGANISM(S): Mus musculus 
2012-04-21 | E-GEOD-35038 | biostudies-arrayexpress
UnknownEmergence and evolutionary analysis of the human DDR network: implications in comparative genomics and downstream analyses.
Not available
S-EPMC3969565 | biostudies-literature
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