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MetabolomicsA lipidomic human population and translational feeding study of hepatic steatosis and de novo lipogenesis (Human plasma assay)
Background: Diet is a major contributor to metabolic disease risk, but there is controversy as to whether increased incidences of diseases such as non-alcoholic fatty liver disease arise from consumption of saturated fats or free sugars. Our aims were to investigate whether a sub-set of TAGs were as...
2018-03-13 | MTBLS616 | MetaboLights
MetabolomicsA lipidomic human population and translational feeding study of hepatic steatosis and de novo lipogenesis (Murine liver assay)
Background: Diet is a major contributor to metabolic disease risk, but there is controversy as to whether increased incidences of diseases such as non-alcoholic fatty liver disease arise from consumption of saturated fats or free sugars. Our aims were to investigate whether a sub-set of TAGs were as...
2018-03-12 | MTBLS614 | MetaboLights
TranscriptomicsAltered de novo lipogenesis contributes to low adipose stores in cystic fibrosis mice.
Cystic fibrosis (CF) mouse models exhibit exocrine pancreatic function yet do not develop adipose stores to the levels of non-CF mice. CF mice homozygous for the Cftr mutation (F508del) at 3 weeks (post-weaning) and 6 weeks (young adult) of age had markedly less adipose tissue than non-CF mice. Both...
ORGANISM(S): Mus musculus 
2012-06-17 | E-GEOD-33319 | biostudies-arrayexpress
ProteomicsFASN-dependent de novo lipogenesis is required for brain development
Fate and behaviour of neural progenitor cells is tightly regulated during mammalian brain development. Metabolic pathways, such as glycolysis and oxidative phosphorylation, that are required for supplying energy and providing molecular building blocks to generate cells, govern progenitor function. H...
ORGANISM(S): Homo sapiens (Human) 
2022-01-14 | PXD026110 | Pride
Fasn Human Mouse Lipogenesis Brain development Brain organoids 
TranscriptomicsGene Expression in the Human Mammary Epithelium in response to consumption of high fat (H-FAT) and high carbohdyrate (H-CHO) diets.
Mammary gland (MG) de novo lipogenesis contributes significantly to milk fat in animals but little is known in humans. We hypothesized that de novo lipogenesis, as reflected by incorporation of 13C carbons from [U-13C]glucose into fatty acids (FAs) and glycerol in triglycerides (TG), will be greate...
ORGANISM(S): Homo sapiens 
2014-05-19 | E-GEOD-51874 | biostudies-arrayexpress
ProteomicsSOCS5-RBMX stimulates SREBP1-mediated lipogenesis to promote metastasis in HCC
SOCS5 stimulate the promoter of SREBP1 to induce de novo lipogenesis to promote HCC metastasis
ORGANISM(S): Homo Sapiens 
2024-01-22 | PXD048740 |
GenomicsCharacterization of an in vitro steatosis model for modelling the activated de novo lipogenesis
Characterization of an in vitro steatosis model for modelling the activated de novo lipogenesis
PRJNA933217 | ENA
TranscriptomicsAnalysis of porcine adipose tissue transcriptome reveals differences in de novo fatty acid synthesis in pigs with divergent muscle fatty acid composition
In pigs, adipose tissue is one of the principal organs involved in the regulation of lipid metabolism. It is particulary involved in the overall fatty acid synthesis with consequences in other lipid-target organs such as muscles and the liver. With this in mind, we have used massive, parallel high-t...
ORGANISM(S): Sus scrofa 
2014-03-31 | E-GEOD-52012 | biostudies-arrayexpress
GenomicsMiR-29 regulates de novo lipogenesis and controls circulating triglyceride levels in a Sirt1-dependent manner
MiR-29 regulates de novo lipogenesis and controls circulating triglyceride levels in a Sirt1-dependent manner
PRJNA531687 | ENA
ProteomicsDe novo lipogenesis as a therapeutic target
Inhibition of the de novo lipogenesis established the connections between the role of the onco-metabolic pathway regulating diverse cell survival processes which suggest targeting these marker enzymes can be of great use in terms of CAC diagnosis, treatment, and further management. In this study we ...
ORGANISM(S): Homo Sapiens 
2025-11-03 | PXD031127 | panorama
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