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GenomicsGenome-wide maps of WT and over-expressing CenH3/CENP-A in Human HeLa S3 cells
Centromeres are essential to ensure proper chromosome segregation in eukaryotes. Their definition relies on the presence of a centromere-specific H3 histone variant CenH3, known as CENP-A in mammals. Its overexpression in aggressive cancers raises questions concerning its effect on chromatin dynamic...
ORGANISM(S): Homo sapiens 
2014-02-12 | E-GEOD-42951 | biostudies-arrayexpress
GenomicsGlutamine methylation on Histone H2A is an RNA Polymerase I dedicated modification
Nucleosomes are decorated with numerous post-translational modifications capable of influencing many DNA processes. Here, we describe a new class of modification, methylation of glutamine, occurring on yeast histone H2A at position 105 (Q105) and human H2A at Q104. We identify Nop1 as the methyltran...
ORGANISM(S): Saccharomyces cerevisiae 
2014-01-21 | E-MTAB-1447 | biostudies-arrayexpress
ProteomicsMS data for Chp1 is a dedicated chaperone at the ribosome that safeguards eEF1A biogenesis
Cotranslational protein folding depends on general chaperones that engage highly diverse nascent chains at the ribosomes. It is not clear how this promiscuous mechanism ensure efficient production of challenging clients such as highly expressed proteins. Here we find that the biogenesis of the abund...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-06-16 | PXD043391 | Pride
Ribosome-associated chaperone Hsf1 activation Eef1a biogenesis 
GenomicsDedicated chaperone at the ribosome safeguards the proteostasis network during eEF1A biogenesis
Dedicated chaperone at the ribosome safeguards the proteostasis network during eEF1A biogenesis
PRJNA915314 | ENA
GenomicsPDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5
PDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5
PRJNA634665 | ENA
UnknownConformational selection underlies recognition of a molybdoenzyme by its dedicated chaperone.
Not available
S-EPMC3501500 | biostudies-literature
TranscriptomicsDedicated chaperone at the ribosome safeguards the proteostasis network during eEF1A biogenesis
Cotranslational protein folding depends on general chaperones that engage highly diverse nascent chains at the ribosomes. Here we find that the universal cotranslational machinery adapts to accommodate the challenging biogenesis of abundantly expressed eukaryotic translation elongation factor 1A (eE...
ORGANISM(S): Saccharomyces cerevisiae 
2024-01-16 | GSE221651 | GEO
TranscriptomicsPDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5
PDCD2 is an evolutionarily conserved protein that is essential for cell proliferation and embryonic development. To date, however, the function of PDCD2 underlying its fundamental cellular role has remained elusive. Here we used quantitative proteomics approaches to define the protein-protein intera...
ORGANISM(S): Homo sapiens 
2020-09-01 | GSE151094 | GEO
ProteomicsExploration of the proxiOME of large subunit ribosomal proteins reveals Acl1 and Bcl1 as cooperating dedicated chaperones of Rpl1
In eukaryotes, most newly synthesized ribosomal proteins (r-proteins) need to rapidly and safely get into the nucleus to reach their assembly site on pre-ribosomal particles. However, only for few r-proteins tailored support mechanisms involving so-called dedicated chaperones could so far be reveale...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-04-14 | PXD070550 | Pride
Acl1  bcl1  ul1  dedicated chaperone  ribosomal protein  ribosome biogenesis  nuclear import  importin  karyopherin  yeast  turboid  proximity labelling  proxiome. 
UnknownThe Dedicated Chaperone Acl4 Escorts Ribosomal Protein Rpl4 to Its Nuclear Pre-60S Assembly Site.
Not available
S-EPMC4598080 | biostudies-literature
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