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MetabolomicsHighly sensitive feature detection for high resolution LC/MS

BACKGROUND: Liquid chromatography coupled to mass spectrometry (LC/MS) is an important analytical technology for e.g. metabolomics experiments. Determining the boundaries, centres and intensities of the two-dimensional signals in the LC/MS raw data is called feature detection. Fo...

2020-01-15 | MTBLS1430 | MetaboLights
MetabolomicsA data set of 255000 randomly selected and manually classified extracted ion chromatograms for evaluation of peak detection methods

Nontargeted mass spectrometry (MS) has become an important method over the last years in the fields of metabolomics and environmental research. While more and more algorithms and workflows become available to process a large number of data sets nontargeted, there still exist few manually evaluate...

2020-05-26 | MTBLS1455 | MetaboLights
MetabolomicsDetection Limits of Blood Metabolites at Physiological Concentrations Using Benchtop 1H NMR

Commercial low-field (LF) magnetic resonance spectroscopy (MRS) offers a route to rapid and repeated \textit{in vivo} metabolite tracking, however its sensitivity and interpretability at physiological concentrations remain underexplored. Here we evaluate the performance of an 80 MHz benchtop nucl...

2025-12-29 | MTBLS6262 | MetaboLights
MetabolomicsHUMAN Ring Trial - Standards detection - Reverse phase

To better understand the effect of different LC-MS setups on metabolite detection, five laboratories analyzed 1298 standard compounds obtained from the MetaSci metabolite standard library, classified as 'Human Endosome' (HE), 'Food Exposome' (FE), 'Chemical Exposome' (CE), 'Microbiota Exposome' (...

2026-04-24 | MTBLS14343 | MetaboLights
MetabolomicsA blood-based metabolic signature for earlier detection of lung cancer

Metabolomic profiling was applied to 1,259 sera collected within five years of a lung cancer diagnosis and 8,470 non-case sera from ever-smoker participants in the Prostate Lung Colorectal and Ovarian (PLCO) Study to identify metabolic signatures for the earlier detection of lung cancer. We devel...

2026-08-20 | MTBLS15406 | MetaboLights
MetabolomicsDetection and Analysis of Rhizosphere Metabolites
To evaluate whether maternal nitrogen histories influenced the rhizosphere metabolite profiles of offspring plants under contrasting soil N availability, seeds from different nitrogen-history maternal lineages were sown into soils established under either N0 (no additional N input) or N2 (2 g N per ...
2026-05-18 | MTBLS14515 | MetaboLights
MetabolomicsPolymicrobial detection and metabolomics in saliva of children with early childhood caries

Cariogenic microorganisms as well as salivary metabolic status in early childhood caries (ECC) have been reported to differ from that in adult caries. The main aim of this study was to identify specific microbial species and salivary metabolites in children with ECC using species-specific qPCR an...

2024-11-12 | MTBLS10890 | MetaboLights
MetabolomicsIntegrating genomics and multi‐platform metabolomics enables metabolite QTL detection in breeding‐relevant apple germplasm
Apple (Malus × domestica) has commercial and nutritional value, but breeding constraints of tree crops limit varietal improvement. Marker-assisted selection minimizes these drawbacks, but breeders lack applications for targeting fruit phytochemicals. To understand genotype-phytochemical associations...
2021-09-21 | MTBLS2327 | MetaboLights
MetabolomicsMetabolite detection and analysis of bacterial strains
This study investigated whether P. oxydans-secreted metabolites function as upstream metabolic signals that modulate host responses. We therefore compared the extracellular metabolomic profiles of P. oxydans cultured under control conditions and under 10% PEG 6000-induced osmotic stress.
2026-07-03 | MTBLS14926 | MetaboLights
MetabolomicsDetection and analysis of microbial strain secretions
Integrating trait associations and network topology prioritized two culturable, legacy-linked taxa, Sphingomonas montis and Pseudarthrobacter oxydans, associated with nitrogen uptake and network centrality, respectively, which were assembled into the minimal two-member synthetic community.
2026-05-16 | MTBLS14501 | MetaboLights
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