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TranscriptomicsDirect Reprogramming of Fibroblasts into Epiblast Stem Cells
Embryonic stem cells (ESCs), which are derived from the primitive ectoderm of pre-implantation blastocysts, are pluripotent cells and can thus contribute to the formation of all somatic cell lineages in chimeric animals. Similarly, epiblast stem cells (EpiSCs), which are derived from epiblast tissu...
ORGANISM(S): Mus musculus 
2010-12-08 | E-GEOD-21516 | biostudies-arrayexpress
ProteomicsTMT analysis of early proteome events in direct cardiomyocyte reprogramming
Direct reprogramming of fibroblasts into cardiomyocyte-like cells (iCM) holds great potential for heart regeneration and disease modeling and may lead to future therapeutic applications in human patients with heart disease. Currently, the application of this technology is limited by our lack of unde...
ORGANISM(S): Mus musculus (Mouse) 
2018-02-19 | PXD006152 | Pride
Mef Gmt Orbitrap velos Hcd Fibroblast 
MetabolomicsDNA-PKcs drives CKD progression by activating TAF7/RAPTOR/mTORC1 signaling-mediated metabolic reprogramming

Kidney injury initiates epithelial dedifferentiation and myofibroblast activation during the progression of chronic kidney disease (CKD). Herein, we found that the expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) was significantly increased in the kidney tissues of both CKD...

2023-01-25 | MTBLS5971 | MetaboLights
MetabolomicsSexual Propagation Enhances Tea Quality Through Rhizosphere Microbiome Assembly and Metabolic Reprogramming in Camellia sinensis
Tea quality is primarily determined by the accumulation of specialized metabolites in fresh leaves; however, the mechanisms by which propagation methods influence tea qual-ity through plant–soil–microbiome interactions remain poorly understood. Here, sexually propagated (SR) and asexually propagated...
2026-08-05 | MTBLS15257 | MetaboLights
TranscriptomicsDIRECT CONVERSION OF FIBROBLASTS INTO FUNCTIONAL ASTROCYTES BY DEFINED TRANSCRIPTION FACTORS
Direct cell reprogramming has enabled the direct conversion of skin fibroblasts into functional neurons and oligodendrocytes using a minimal set of cell lineage-specific transcription factors. This approach has substantial advantages since it is rapid and simple, generating the cell type of interest...
ORGANISM(S): Mus musculus 
2015-06-22 | E-GEOD-59018 | biostudies-arrayexpress
TranscriptomicsReversal of Aberrant Cancer Methylome and Transcriptome upon Direct Reprogramming of Lung Cancer Cells.
This SuperSeries is composed of the following subset Series: GSE35911: Reversal of Aberrant Cancer Methylome and Transcriptome upon Direct Reprogramming of Lung Cancer Cells [Expression] GSE35912: Reversal of Aberrant Cancer Methylome and Transcriptome upon Direct Reprogramming of Lung Cancer Cells ...
ORGANISM(S): Homo sapiens 
2012-08-27 | E-GEOD-35913 | biostudies-arrayexpress
TranscriptomicsPromotion of Direct Reprogramming by Glis1
Induced pluripotent stem cells (iPSC) are generated from somatic cells by the transgene expression of three transcription factors Oct3/4, Sox2, and Klf4 (OSK), albeit at a low efficiency. The protooncogene c-Myc enhances the efficiency of iPSC generation by OSK, but it also increases the tumorigenic...
ORGANISM(S): Mus musculus 
2011-06-10 | E-GEOD-26429 | biostudies-arrayexpress
TranscriptomicsOptimization of Direct Fibroblast Reprogramming to Cardiomyocytes Using Calcium Activity as a Functional Measure of Success
Direct conversion of fibroblasts to induced cardiomyocytes (iCMs) has great potential for regenerative medicine. Recent publications have reported significant progress, but the evaluation of reprogramming has relied upon non-functional measures such as flow cytometry for cardiomyocyte markers or GFP...
ORGANISM(S): Mus musculus 
2013-04-22 | E-GEOD-45274 | biostudies-arrayexpress
TranscriptomicsIdentification and successful negotiation of a metabolic checkpoint in direct neuronal reprogramming
Despite the widespread interest in direct neuronal reprogramming, the mechanisms underpinning fate conversion remain largely unknown. Our study revealed a critical time point after which cells either successfully convert into neurons or succumb to cell death. Co-transduction with Bcl-2 greatly impro...
ORGANISM(S): Mus musculus 
2016-06-29 | E-GEOD-70921 | biostudies-arrayexpress
MetabolomicsBifidobacterium animalis subsp. lactis BD1 restores neurotransmitter homeostasis in chronically stressed mice via tryptophan metabolic reprogramming

Background: Chronic psychological stress is a major precipitating factor for neuropsychiatric disorders, yet the underlying mechanisms remain incompletely understood. The gut-brain axis has emerged as a critical regulator of mood and behavior, but how specific commensal microbes modulate host neu...

2025-10-23 | MTBLS13208 | MetaboLights
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