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MetabolomicsMulti-Omics Approach to Elucidate Cerebrospinal Fluid Changes in Dogs with Intervertebral Disc Herniation
Herniation of the intervertebral disc (IVDH) is the most common cause of neurological and intervertebral disc degeneration-related diseases. Since the disc starts to degenerate before it can be observed by currently available diagnostic methods, there is an urgent need for novel diagnostic approache...
2021-11-04 | MTBLS2689 | MetaboLights
MetabolomicsImaginal disc growth factor maintains cuticle structure and controls melanization in the spot pattern formation of Bombyx mori

The complex stripes and patterns of insects play key roles in behavior and ecology. However, the fine-scale regulation mechanisms underlying pigment formation and morphological divergence remain largely unelucidated. Here we demonstrated that imaginal disc growth factor (IDGF) maintains cuticle s...

2020-09-20 | MTBLS1825 | MetaboLights
ProteomicsA proteomic architectural landscape of the healthy and aging human intervertebral disc
The intervertebral disc (IVD) is a joint in the spine that facilitates daily physical activity, comprising of the central nucleus pulposus (NP), surrounded by the annulus fibrosus (AF) and sandwiched between two cartilage endplates that function together as a unit. Changes to the IVD occur with agin...
ORGANISM(S): Homo sapiens (Human) 
2021-01-29 | PXD017740 | Pride
Proteomics Intervertebral disc Aging 
TranscriptomicsHuman notochordal cell transcriptome in the developing intervertebral disc
The adult nucleus pulposus originates from the embryonic notochord, but loss of notochordal cells with skeletal maturity in humans is believed to initiate intervertebral disc degeneration. Thus, defining the phenotype of human embryonic/fetal notochordal cells is essential for understanding their ro...
ORGANISM(S): Homo sapiens 
2018-08-29 | E-MTAB-6868 | biostudies-arrayexpress
TranscriptomicsThe long noncoding RNA expression profile of human intervertebral disc degeneration identified by microarray analysis
In addition to the well-known short noncoding RNAs as miRNAs, increasing evidence suggests that long noncoding RNAs (lncRNAs) act as key regulators in a wide aspect of biologic processes. Dysregulated expression of lncRNAs has been demonstrated being implicated in a variety of human diseases. Howeve...
ORGANISM(S): Homo sapiens 
2014-11-17 | E-GEOD-56081 | biostudies-arrayexpress
ProteomicsMass spectrometry analysis of degenerated human intervertebral disc tissues
Mass spectrometry analysis of degenerated human intervertebral disc tissues obtained during elective surgery to treat low back pain
ORGANISM(S): Homo sapiens (Human) 
2025-02-14 | PXD056620 | Pride
Human Degeneration Mass spectometry Intervertebral disc Dda 
TranscriptomicsDownregulation of miR-760 Causes Human Intervertebral Disc Degeneration by Targeting the MyD88/Nuclear Factor-Kappa B Signaling Pathway
Dysregulation of microRNAs (miRNAs) plays a critical role in the development of intervertebral disc degeneration (IDD). In this study, we present evidence from in vitro and in vivo research to elucidate the mechanism underlying the role of miR-760 in IDD. miRNA microarray and quantitative reverse tr...
ORGANISM(S): Homo sapiens 
2022-03-17 | E-MTAB-11554 | biostudies-arrayexpress
TranscriptomicsMolecular Profiling of the Developing Axial Skeleton: A role for Tgfbr2 in the Development of the Intervertebral Disc.
This SuperSeries is composed of the following subset Series: GSE18647: Gene expression in embryonic intervertebral disc and vertebrae. GSE18648: TGF-beta and BMP mediated gene expression in cultured sclerotome. Refer to individual Series
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-18649 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of bovine nucleus pulposus, carticular cartilage and annulus fibrosus cells to further determine expression in normal and degenerate human intervertebral disc
The aim of this transcription profiling study was to identify novel genes that could be used to distinguish bovine Nucleus pulposus (NP) cells from articular cartilage (AC) and annulus fibrosus (AF) cells and to further determine their expression in normal and degenerate human intervertebral disc (I...
ORGANISM(S): Bos taurus 
2010-03-05 | E-MEXP-2291 | biostudies-arrayexpress
ProteomicsMatrisome remodelling during Intervertebral Disc development and ageing
Intervertebral disc (IVD) degeneration is often the cause of low back pain. Degeneration occurs with age and is accompanied by extracellular matrix (ECM) depletion, culminating in nucleus pulpous (NP) extrusion and IVD destruction. The changes that occur in the disc with age have been under investi...
ORGANISM(S): Bos taurus (Bovine) 
2017-09-25 | PXD005616 | Pride
Foetus Extracellular matrix Development Intervertebral disc Ageing 
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