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TranscriptomicsThe exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development
Wingless (Wg)/Wnt signaling is conserved in all metazoan animals and plays critical roles in development. The Wg/Wnt morphogen reception is essential for signal activation, whose activity is mediated through the receptor complex and a scaffold protein Dishevelled (Dsh). We report here that the exon ...
ORGANISM(S): Drosophila melanogaster 
2016-08-19 | E-GEOD-81220 | biostudies-arrayexpress
ProteomicsDLG1 functions upstream of SDCCAG3 and IFT20 to control ciliary targeting of polycystin-2
Polarized vesicular trafficking directs specific receptors and ion channels to cilia, but the underlying mechanisms are poorly understood. Here we describe a role for DLG1, a core component of the Scribble polarity complex, in regulating ciliary protein trafficking in kidney epithelial cells. Condit...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD051906 | Pride
Dlg1 Bioid2 Primary cilia 
ProteomicsDLG1 functions upstream of SDCCAG3 and IFT20 to control ciliary targeting of polycystin-2
Polarized vesicular trafficking directs specific receptors and ion channels to cilia, but the underlying mechanisms are poorly understood. Here we describe a role for DLG1, a core component of the Scribble polarity complex, in regulating ciliary protein trafficking in kidney epithelial cells. Condit...
ORGANISM(S): Homo sapiens (Human) 
2024-05-14 | PXD051912 | Pride
Dlg1 Bioid2 Primary cilia 
GenomicsA DLG1-ARHGAP31-CDC42 axis regulates the Wnt response in intestinal stem cells
A DLG1-ARHGAP31-CDC42 axis regulates the Wnt response in intestinal stem cells
PRJNA816060 | ENA
TranscriptomicsA DLG1-ARHGAP31-CDC42 axis regulates the Wnt response in intestinal stem cells
A central factor in maintenance of tissue integrity is the response of stem cells to variations in the levels of niche signals. In the gut, intestinal stem cells (ISCs) depend on Wnt ligands for self-renewal and proliferation. Transient increases in Wnt signaling promote regeneration after injury or...
ORGANISM(S): Mus musculus 
2023-01-15 | GSE198573 | GEO
UnknownCharacterization of in vivo Dlg1 deletion on T cell development and function.
Not available
S-EPMC3445470 | biostudies-literature
UnknownDLG1 functions upstream of SDCCAG3 and IFT20 to control ciliary targeting of polycystin-2.
Not available
S-EPMC10659422 | biostudies-literature
UnknownDLG1 functions upstream of SDCCAG3 and IFT20 to control ciliary targeting of polycystin-2.
Not available
S-EPMC11239879 | biostudies-literature
UnknownDlg1 controls planar spindle orientation in the neuroepithelium through direct interaction with LGN.
Not available
S-EPMC4164945 | biostudies-literature
UnknownLncRNA DLG1-AS1 Promotes Cancer Cell Proliferation in Triple Negative Breast Cancer by Downregulating miR-203.
Not available
S-EPMC7462810 | biostudies-literature
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