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TranscriptomicsDNA damage signaling gene array on SMA mouse skeletal muscle
A commercially available gene array (SABiosciences array PAMM-029ZD-12) was used to assay gene expression in skeletal muscle of SMA mice and control littermates. The Taiwanese severe SMA mouse model was used (Hsieh-Li et al. 2000). The array included 84 genes associated with DNA damage detection, DN...
ORGANISM(S): Mus musculus 
2014-03-03 | E-GEOD-55481 | biostudies-arrayexpress
ProteomicsInhibition of nuclear PTEN tyrosine phosphorylation enhances glioma radiation sensitivity through attenuated DNA repair
Glioblastoma (GBM) is the most lethal brain tumour that occurs in adults and treatment for GBM has been largely unsuccessful. Ionizing radiation (IR) and chemotherapeutic agents are employed as standard of care treatment for GBM patients and both result in DNA damage. Previous data identified phosph...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-08-07 | MSV000081423 | MassIVE
TranscriptomicsDNA Damage Response and Inflammatory Signaling Limit the MLL-ENL-induced Leukemogenesis in vivo
Activation of the MLL-ENL-ERtm oncogene initiates aberrant proliferation of myeloid progenitors. Here, we show induction of a fail-safe mechanism mediated by the DNA damage response (DDR) machinery that results in activation of the ATR/ATM-Chk1/Chk2-p53/p21 checkpoint and cellular senescence at earl...
ORGANISM(S): Mus musculus 
2012-04-21 | E-GEOD-35038 | biostudies-arrayexpress
ModelsIwamoto2010 - Cell cycle reponse to DNA damage
After DNA damage, cells activate p53, a tumor suppressor gene, and select a cell fate (e.g., DNA repair, cell cycle arrest, or apoptosis). Recently, a p53 oscillatory behavior was observed following DNA damage. However, the relationship between this p53 oscillation and cell-fate selection is unclear...
2024-09-02 | BIOMD0000000939 | BioModels
TranscriptomicsDNA damage responses and Mec1p
Eukaryotic cells respond to DNA damage by arresting the cell cycle and modulating gene expression to ensure efficient DNA repair. The human ATR kinase and its homolog in yeast, MEC1, play central roles in transducing the damage signal. To characterize the role of the Mec1 pathway in modulating the c...
ORGANISM(S): Saccharomyces cerevisiae 
2005-09-24 | E-GEOD-3358 | biostudies-arrayexpress
GenomicsAccumulating DNA damage and insufficient DNA repair in senescent cells underlie persistent DNA damage signaling
Accumulating DNA damage and insufficient DNA repair in senescent cells underlie persistent DNA damage signaling
PRJNA643685 | ENA
ModelsIntegrated Model of DNA Damage Response and p53 Signaling in ATM/ATR-Deficient Ataxia Telangiectasia: Exploring the Therapeutic Roles of Possible repurposed drugs
Comprehensive Model Description Overview This model simulates the cellular response to DNA damage under conditions of ATM/ATR deficiency—such as in ataxia telangiectasia—and predicts the potential benefits of drug repositioning with Omaveloxolone and spermidine. It integrates several interconnected...
2025-11-25 | MODEL2503190002 | BioModels
TranscriptomicsLoss of Caenorhabditis elegans UNG-1 uracil-DNA glycosylase affects apoptosis in response to DNA damaging agents.
The nematode Caenorhabditis elegans has been used extensively to study responses to DNA damage. In contrast, little is known about DNA repair in this organism. C. elegans is unusual in that it encodes few DNA glycosylases and the uracil-DNA glycosylase (UDG) encoded by the ung-1 gene is the only kno...
ORGANISM(S): Caenorhabditis elegans 
2010-06-08 | E-GEOD-21467 | biostudies-arrayexpress
ProteomicsER-associated degradation ligase HRD1 links ER stress to DNA damage repair by modulating the activity of DNA-PKcs
ER-associated degradation ligase HRD1 links ER stress to DNA damage repair by modulating the activity of DNA-PKcs
ORGANISM(S): Homo Sapiens 
2024-08-20 | PXD055020 |
ProteomicsSelective Macrocyclic Peptide Modulators of Lys63-linked Ubiquitin Chains Disrupt DNA Damage Repair
Developing an effective binder for a specific ubiquitin (Ub) chain is a promising approach for modulating various biological processes with potential applications in drug discovery. In this study, we combined the Random Non-standard Peptides Integrated Discovery (RaPID) method and chemical protein s...
ORGANISM(S): Homo sapiens (Human) 
2022-09-19 | PXD035924 | Pride
Ubiquitin Dna damage repair 
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