Sort   by:  
 Page size 
ProteomicsTargeting neddylation is a novel therapeutic strategy for lupus by reconstructing double negative T cell homeostasis
Systemic lupus erythematosus (SLE) is an autoimmune disorder with systemic inflammation, autoantibody accumulation and organ damage. The abnormalities of double-negative (DN) T cells are considered as an important commander of SLE. Neddylation, an important type of protein post-translational modific...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD045686 | Pride
Neddylation  ube2m  systemic lupus erythematosus (sle)  bim  double negative t cells (dn t cells)  apoptosis 
TranscriptomicsMurine DN T-reg cells impart prolonged cardiac allograft survival
Recent studies have demonstrated that both mouse and human alpha beta TCR(+)CD3(+)NK1.1(-)CD4(-)CD8- double-negative regulatory T (DN Treg) cells can suppress Ag-specific immune responses mediated by CD8+ and CD4+ T cells. To identify molecules involved in DN Treg cell function, we generated a panel...
ORGANISM(S): Mus musculus 
2005-07-29 | E-GEOD-3024 | biostudies-arrayexpress
TranscriptomicsGene expression of TCR-alpha/beta CD4- CD8- human T cells
The origin and function of human double negative (DN) TCR-alpha/beta T cells is unknown. They are thought to contribute to the pathogenesis of systemic lupus erythematosus because they expand and accumulate in inflamed organs. Here we provide evidence that human TCR-alpha/beta CD4- CD8- DN T cells...
ORGANISM(S): Homo sapiens 
2009-05-16 | E-GEOD-16130 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse double-negative regulatory T Cells
Lee et al. (2005)Expression Profiling of Murine Double-Negative Regulatory T Cells Suggest Mechanisms for Prolonged Cardiac Allograft Survival. The Journal of Immunology, 2005, 174: 4535 4544. Type 2 experiment where functional DN T-reg cells (CN4 or TN12) were cy-3 labeled and co-hybridized with n...
ORGANISM(S): Mus musculus 
2005-07-21 | E-SMDB-3283 | biostudies-arrayexpress
TranscriptomicsCD3/CD28 Stimulated versus unstimulated Double-negative T Cells From Sooty Mangabeys
Transcriptional profiling of Double Negative (CD4-/CD8-) T-cells isolated from SIV infected Sooty Mangebys. DN T-cells were stimulated through the T-Cell receptor using anti CD3/CD28 antibodies for 4 hours and compared to unstimulated DN T-cells. Two condition experiment, Stimulated vs Unstimulated....
ORGANISM(S): Cercocebus atys 
2012-12-31 | E-GEOD-40781 | biostudies-arrayexpress
TranscriptomicsThe DNA methylation signature of human TCRαβ+CD4-CD8- double negative T cells reveals CG demethylation and a unique epigenetic architecture permissive to a broad stimulatory immune response
T cell receptor (TCR) αβ+ CD4- CD8- double negative T cells represent a rare T cell subset implicated in the pathogenesis of several autoimmune diseases. In this study, we investigated the DNA methylation signature of double negative T cells to gain insight into the epigenetic architecture and trans...
ORGANISM(S): Homo sapiens 
2015-09-01 | E-GEOD-61195 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-seq to investigate transcriptional profiles of thymic double negative T cells in WT, NPM-ALK(Tg/+) and NPM-ALK(Tg/+)Cdk6-/-Stat5b-/- mice
To examine transcriptional differences in thymic double negative (DN) T cells between wildtype (WT), NPM-ALK(Tg/+) and NPM-ALK(Tg/+)Cdk6-/-Stat5b-/- mice, single-cell RNA sequencing (scRNA-seq) was performed on fluorescence-activated cell sorted (FACS) DN T cells. The aim was to understand how genet...
ORGANISM(S): Mus musculus 
2026-07-24 | E-MTAB-15478 | biostudies-arrayexpress
TranscriptomicsKrüppel-like factor 4 regulates T cell function
Krüppel-like factor 4 (Klf4), a transcription factor mediating context-dependent activation or repression, plays a key role in maintaining pluripotency of stem cells and in regulating cell differentiation. However, the precise function of Klf4 in T cell development and differentiation is largely unk...
ORGANISM(S): Mus musculus 
2011-06-24 | E-GEOD-24880 | biostudies-arrayexpress
GenomicsLupus milieu favors the conversion of self-reactive CD8 T cells to IL-17 producing double negative T cells
Lupus milieu favors the conversion of self-reactive CD8 T cells to IL-17 producing double negative T cells
PRJNA627722 | ENA
TranscriptomicsExpression and regulation of lincRNAs during T cell development and differentiation
Although lincRNAs are implicated in regulating gene expression in various tissues, little is known about lincRNA transcriptomes in the T cell lineages. Here we identify 1,524 lincRNAs in 42 T cell samples from early T cell progenitors to terminally differentiated T helper subsets. Our analysis revea...
ORGANISM(S): Mus musculus 
2013-09-23 | E-GEOD-48138 | biostudies-arrayexpress
Sort   by:  
 Page size