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MetabolomicsClinical Application Value of Ceramide and Sphingomyelin as Biomarkers for the Diagnosis of Drug-Induced Liver Injury

Background : Drug-induced liver injury (DILI) is a serious health concern that presents challenges in early detection and accurate diagnosis, thereby complicating the treatment of this liver disease. Therefore, it is crucial to explore specific biomarkers to improve the accuracy of diagnosing DIL...

2025-07-23 | MTBLS12765 | MetaboLights
MetabolomicsProtective Effects of Cordycepin against Oxaliplatin-Associated Drug-Induced Fatty Liver Disease and Preliminary Mechanistic Insights

Oxaliplatin (OXA) is a chemotherapeutic agent used to treat multiple malignancies. Although it predominantly causes hepatic sinusoidal obstruction syndrome, it also induces drug-induced fatty liver disease (DIFLD) via lipid metabolic dysregulation and oxidative stress, which persists post-cessati...

2025-09-04 | MTBLS12938 | MetaboLights
ProteomicsProteomic-based identification of APCS as candidate protein for diagnosis of patients exhibiting Anti-tubercular drug induced liver injury
In the present study, the proteomics approach identified potential protein signatures with high discriminative ability in TB patients with and without drug-induced liver injury which might play a crucial role in developing Anti-tubercular drug-induced liver injury.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-12 | MSV000088373 | MassIVE
ProteomicsTandem Mass Tag-Based Quantitative Proteomic Profiling Identifies Novel Serum Biomarkers of Drug-Induced Liver Injury in Humans
Diagnosis of drug-induced liver injury (DILI) and its distinction from other liver diseases are significant challenges in drug development and clinical practice. In this study we identify, confirm, and replicate the biomarker performance characteristics of candidate proteins in a cohort of patients ...
ORGANISM(S): Homo Sapiens 
2024-01-04 | PXD034882 | panorama
ProteomicsDrug Induced Liver Injury Biomarker Discovery Data
Discovery proteomics was conducted on serum samples using tandem mass tagging for relative quantitation to discover potential new biomarkers of DILI.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-07-01 | MSV000089782 | MassIVE
GenomicNIDDK Drug-Induced Liver Injury Network (DILIN)

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) has established the Drug-Induced Liver Injury Network (DILIN) to collect and analyze cases of severe liver injury caused by prescription drugs, over-the-counter drugs, and alternative medicines, such as herbal products a...

phs000663 | dbGaP
MetabolomicsMulti-omics uncovers formononetin's protection against antibiotic-induced liver injury via microbiota-metabolite-transcriptome coordination

Tetracycline antibiotics (TETs) cause hepatotoxicity via gut-liver axis disruption and oxidative stress. This study evaluated whether formononetin (FMN), a natural isoflavone, alleviates TET-induced liver injury through microbiota-metabolite-transcriptome coordination. Using network toxicology an...

2025-10-14 | MTBLS13138 | MetaboLights
MetabolomicsMulti-omics uncovers formononetin's protection against antibiotic-induced liver injury via microbiota-metabolite-transcriptome coordination

Tetracycline antibiotics (TETs) cause hepatotoxicity via gut-liver axis disruption and oxidative stress. This study evaluated whether formononetin (FMN), a natural isoflavone, alleviates TET-induced liver injury through microbiota-metabolite-transcriptome coordination. Using network toxicology an...

2025-10-17 | MTBLS13161 | MetaboLights
TranscriptomicsDual function of Jnk1 and Jnk2 in hepatocytes is essential to protect against toxic liver injury
BACKGROUND & AIMS: c-Jun N-terminal kinase (JNK)1 and JNK2 are expressed in hepatocytes and have overlapping and distinct functions. JNK proteins are activated, via phosphorylation, in response to acetaminophen- or CCl4-induced liver damage; the level of activation correlates with the degree of inju...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-59602 | biostudies-arrayexpress
TranscriptomicsThe genomic responses of mouse liver to diclofenac treatment reveals an immune mediated mechanism of liver injury
Diclofenac (DCL) is a non-steroidal anti-inflammatory drug. Its use can be associated with serious adverse drug reactions most notable myocardial infarction and drug-induced liver injury (DILI). The molecular causes leading to DILI remains unclear and it seems to be multifactorial. The aims of this ...
ORGANISM(S): Mus musculus 
2016-08-09 | E-GEOD-75277 | biostudies-arrayexpress
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