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ProteomicsFunctional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes
Supporting .raw data for "Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes", DOI: 10.15252/embj.2021108823 Related to Figure 1E and EV1A.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-17 | MSV000088403 | MassIVE
ProteomicsInteractome of E1 ubiquitin-activating enzymes and of E2 ubiquitin-conjugating enzymes in human HEK293 cells.
Investigation of E1 ubiquitin-activating enzymes and E2 ubiquitin-conjugating enzymes interactome in human HEK293 cells.
ORGANISM(S): Homo sapiens (Human) 
2023-11-14 | PXD042361 | Pride
E1 ubiquitin-activating enzymes  e2 ubiquitin-conjugating enzymes  ubiquitin  human cells  interactome. 
ProteomicsTargeted protein degradation using E2 ubiquitin-conjugating enzymes
Proteins can be targeted for degradation by using engineered molecular conjugates to enhance their interaction with eukaryotic ubiquitination machinery. For instance, the fusion of an E3 ubiquitin ligase to a suitable target binding domain creates a biological ‘Proteolysis-Targeting Chimera’ (bioPRO...
ORGANISM(S): Homo sapiens (Human) 
2024-09-23 | PXD041225 | Pride
Bioprotac 
ProteomicsAuranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterificlation to E2 ubiquitin-conjugating enzymes
UBA1 is the primary E1 ubiquitin-activating enzyme, regulating stability and function of numerous proteins via initiating their ubiquitination. Decreased or insufficient ubiquitination can cause or drive aging and many deadly diseases. Therefore, a small-molecule UBA1 activity enhancer could have br...
ORGANISM(S): Homo sapiens (Human) 
2023-07-10 | PXD042558 | Pride
Ubiquitination Uba1 Auranofin 
TranscriptomicsE2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
Ubiquitin and ubiquitin-like proteins (UBLs) are directed to targets by cascades of E1, E2, and E3 enzymes. The largest ubiquitin E3 subclass consists of cullin-RING ligases (CRLs), which contain one each of several cullins (CUL1, -2, -3, -4, or -5) and RING proteins (RBX1 or -2). CRLs are activated...
ORGANISM(S): Mus musculus 
2009-03-23 | E-GEOD-14088 | biostudies-arrayexpress
UnknownE2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1.
Not available
S-EPMC3941643 | biostudies-literature
ProteomicsTomato nuclear proteome reveals the involvement of specific E2 ubiquitin-conjugating enzymes in fruit ripening
Fruits are unique to flowering plants and play a central role in seed maturation and dispersal. Molecular dissection of fruit ripening has received considerable interest because of the biological and dietary significance of fruit. To better understand the regulatory mechanisms underlying fruit ripen...
ORGANISM(S): Solanum lycopersicum 
2014-11-18 | PXD001414 | Pride
Nucleus Fruit ripening Proteomics Tomato Mads-rin Ubiquitination 
GenomicsUBE2J1 is the E2 Ubiquitin Conjugating Enzyme Required for Androgen Receptor Degradation
UBE2J1 is the E2 Ubiquitin Conjugating Enzyme Required for Androgen Receptor Degradation
PRJNA1003118 | ENA
UnknownGenome-wide identification and expression analysis of E2 ubiquitin-conjugating enzymes in tomato.
Not available
S-EPMC5561181 | biostudies-literature
TranscriptomicsExpression data from 17 day old testes of wild type and UBR2-/- mice
Ubiquitylation of histones provides an important mechanism regulating chromatin remodeling and gene expression. Recent studies have revealed ubiquitin ligases involved in histone ubiquitylation, yet the responsible enzymes and the function of histone ubiquitination in spermatogenesis remain unclear....
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-18824 | biostudies-arrayexpress
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