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MetabolomicsCharacteristics of myocardial structure and central carbon metabolism during the early and compensatory stages of cardiac hypertrophy
Cardiac hypertrophy is a classical forerunner of heart failure and myocardial structural and metabolic remodeling are closely associated with cardiac hypertrophy. We aim to investigate the characteristics of myocardial structure and central carbon metabolism of cardiac hypertrophy at different stage...
2024-08-23 | MTBLS10555 | MetaboLights
MetabolomicsTargeted metabolomic profiling of myocardial remodeling after STEMI

Early detection of myocardial remodeling is essential for optimizing outcomes in patients with ST-segment elevation myocardial infarction (STEMI). However, reliable biomarkers for predicting STEMI myocardial remodeling remain scarce.

Targeted metabolomic profiling was performed on plasma ...

2025-09-02 | MTBLS10634 | MetaboLights
ProteomicsIncreased Hemodynamic Load in Early Embryonic Stages Alters Endocardial to Mesenchymal Transition
Normal blood flow is essential for proper heart formation during embryonic development, as abnormal hemodynamic load (blood pressure and shear stress) results in cardiac defects seen in congenital heart disease. However, the progressive detrimental remodeling processes that relate altered blood flow...
ORGANISM(S): Gallus Gallus (ncbitaxon:9031) 
2019-07-17 | MSV000084103 | MassIVE
ProteomicsCardiac tissue remodeling as a new marker to predict cardiac dysfunction induced by radiotherapy.
The contribution of radiotherapy, per se, in late cardiotoxicity remains controversial. An experimental model was developed, in which rat hearts were exposed to a range of ionizing radiation doses, to clarify its impact on the development of early cardiac dysfunction. Rat’s hearts were exposed to da...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-09-08 | PXD033194 | Pride
Gls Cardiac tissue Cardiac muscle Cardiooncology Cardiac dysfunction Radiotherapy 
GenomicsThe role of stretch, tachycardia and sodium-calcium exchanger in induction of early cardiac remodeling
The role of stretch, tachycardia and sodium-calcium exchanger in induction of early cardiac remodeling
PRJNA557667 | ENA
TranscriptomicsTranscriptional effects of CTGF inhibition in a transgenic mouse model of dilated cardiomyopathy
Cardiac structural changes associated with dilated cardiomyopathy (DCM) include cardiomyocyte hypertrophy and myocardial fibrosis. Connective Tissue Growth Factor (CTGF) has been associated with tissue remodeling and is highly expressed in failing hearts. To test if inhibition of CTGF would alter ...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-68857 | biostudies-arrayexpress
TranscriptomicsMolecular Remodeling of Ion Channels in Human Atrial and Ventricular Myocytes Associated with Ischemic Cardiomyopathy
Ischemic cardiomyopathy (ICM) leads to congestive heart failure and can cause sudden cardiac death due to arrhythmia. Existing molecular knowledge base of ICM is rudimentary because of lack of specific attribution to cell type and function. This study was designed to investigate cell-specific molecu...
ORGANISM(S): Homo sapiens 
2010-05-14 | E-GEOD-17294 | biostudies-arrayexpress
TranscriptomicsMyocardial infarction time series single cell RNA-Seq
The outcome of cardiac repair post myocardial infarction is highly dependent on the balance between inflammation and fibrosis, which can lead to adverse ventricular remodeling and failure or early cardiac rupture. In order to profile the dynamic response of the interstitium to cardiac ischemic injur...
ORGANISM(S): Mus musculus 
2020-03-04 | E-MTAB-7895 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-Seq of the mouse heart in response to chronic stress
We characterized single-cell transcriptional profiles of heart ventricles of C57BL/6J female and male mice subjected to a chronic stress, two weeks of continuous administration of Angiotensin II. The cell preparation we sequenced consisted of metabolically active, nucleated non-myocyte cells which ...
ORGANISM(S): Mus musculus 
2020-11-24 | E-MTAB-8810 | biostudies-arrayexpress
TranscriptomicsIntrauterine growth restriction is associated with cardiac ultrastructural and gene expression changes related to the energetic metabolism in a rabbit model
Intrauterine growth restriction (IUGR) affects 7-10% of pregnancies and is associated with cardiovascular remodeling and dysfunction which persists into adulthood. The underlying subcellular remodeling and cardiovascular programming events are still poorly documented. Cardiac muscle is central in th...
ORGANISM(S): Oryctolagus cuniculus 
2013-10-30 | E-GEOD-37860 | biostudies-arrayexpress
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