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TranscriptomicsDifferentially expressed long noncoding RNA expression between periodontal ligament stem cells from healthy periodontal tissue and periodontal ligament stem cells from inflammatory periodontal tissue.
Periodontitis can impair the osteogenic differentiation of human periodontal mesenchymal stem cells, but the underlying molecular mechanisms are still poorly understood. Long noncoding RNAs (lncRNAs) have been demonstrated to play significant roles under both physiologic and pathological conditions....
ORGANISM(S): Homo sapiens 
2016-02-19 | E-GEOD-78074 | biostudies-arrayexpress
ProteomicsH2O2 induced oxidative stress may trigger cellular senescence in retinal photoreceptor cells through modulation of ECM-receptor interaction, oxidative phosphorylation and spliceosome pathways
Photoreceptor cells are highly susceptible to oxidative stress induced damage due to their high metabolic rate. Oxidative stress plays a key role in driving pathological events in several different ocular diseases which lead to retinal degeneration and ultimately blindness. A growing number of studi...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD037329 | Pride
Proteomics  photoreceptor  oxidative stress  retina  ecm receptor interaction signaling pathway  cellular senescence. 
TranscriptomicsThe expression profiles of extracellular matrix-related genes in the presence or absence of IL-17A or -17F as measured with the PCR array in systemic sclerosis (SSc) dermal fibroblasts
We examined the effect of IL-17 signaling pathway on extracellular matrix (ECM) expression and the involvement of IL-17 signaling pathway in pathogenesis of SSc. To identify differences in the expression pattern of ECM genes in IL-17A- or IL-17F-treated cells, we performed PCR array analysis, consis...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-33581 | biostudies-arrayexpress
TranscriptomicsConstitutively active RhoA (RhoAV14) expression and regulation of acqeous humor outflow dynamics
Impaired drainage of aqueous humor through the trabecular meshwork (TM) culminating in increased intraocular pressure is a major risk factor for glaucoma, a leading cause of blindness worldwide. Regulation of aqueous humor drainage through the TM, however, is poorly understood. The role of RhoA GTPa...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-9288 | biostudies-arrayexpress
UnknownTranscription Analysis of the THBS2 Gene through Regulation by Potential Noncoding Diagnostic Biomarkers and Oncogenes of Gastric Cancer in the ECM-Receptor Interaction Signaling Pathway: Integrated System Biology and Experimental Investigation.
Not available
S-EPMC10756743 | biostudies-literature
UnknownTranscriptome profiling revealed multiple genes and ECM-receptor interaction pathways that may be associated with breast cancer.
Not available
S-EPMC6554968 | biostudies-literature
TranscriptomicsGene expression profiles of ovarian cancer cells by inhibiting Hh signaling
Analysis of gene expression levels in response to inhibition of Hh signaling in ovarian cancer cells using a cDNA microarray technique. Results suggest that 208 genes (50.5%) were up-regulated and 204 gene (49.5%) were down-regulated after GANT61 treatment.The focal adhesion and ECM-receptor inter...
ORGANISM(S): Homo sapiens 
2014-01-15 | E-GEOD-53464 | biostudies-arrayexpress
UnknownThe prognostic value of bioinformatics analysis of ECM receptor signaling pathways and LAMB1 identification as a promising prognostic biomarker of lung adenocarcinoma.
Not available
S-EPMC11419468 | biostudies-literature
TranscriptomicsWhole genome expression data from pre-auricular and post-auricular skin tissues
Photoaging is cumulative damage that is caused by chronic, repeated solar radiation exposure to skin. Its molecular mechanisms are poorly understood at the level of global gene expression.This study set out to uncover genes and functional modules involved in photoaging at the level of transcription,...
ORGANISM(S): Homo sapiens 
2014-02-07 | E-GEOD-38308 | biostudies-arrayexpress
TranscriptomicsHost cell responses to persistent mycoplasmas--different stages in infection of HeLa cells with Mycoplasma hominis
M. hominis adherence, colonisation and invasion of HeLa cells were characterised in a time-course study using microarray-based analysis of the HeLa cell transcriptome: 0 h to monitor the baseline of transcription, 4 h to examine host reactions to mycoplasma attachment, 48 h to capture in addition th...
ORGANISM(S): Homo sapiens 
2014-02-06 | E-GEOD-54698 | biostudies-arrayexpress
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