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MetabolomicsECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting

The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction is critically dependent on cell-cell communication mediated by exosomes, small ves...

2020-10-07 | MTBLS1969 | MetaboLights
MetabolomicsECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting

The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction is critically dependent on cell-cell communication mediated by exosomes, small ves...

2020-10-07 | MTBLS1977 | MetaboLights
ProteomicsSecretome of rat smooth muscle cells with stretch
The extracellular matrix (ECM) is fundamental to cellular and tissue structural integrity and provides mechanical cues to initiate diverse biological functions1. The quality and quantity of ECM determines tissue stiffness and controls gene expression, cell fate, and cell cycle progression in various...
ORGANISM(S): Rattus Rattus (black Rat) 
2020-03-18 | PXD013915 | JPOST Repository
ProteomicsProteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent fibro-inflammatory signature
The ovarian microenvironment becomes fibrotic and stiff with age due in part to increased stromal collagen and decreased hyaluronan. However, the extracellular matrix (ECM) is a complex network of hundreds of proteins, glycoproteins and glycans which are highly tissue specific and undergo pronounced...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-04-24 | MSV000091790 | MassIVE
GenomicsELK3 controls gastric cancer cell migration and invasion by regulating ECM remodeling-related genes
ELK3 controls gastric cancer cell migration and invasion by regulating ECM remodeling-related genes
PRJNA753553 | ENA
ProteomicsCaught in the act: multiphoton microscopy reveals host extracellular matrix remodeling by a human cancer-avatar model
: Cancer cells facilitate tumor growth by creating favorable tumor micro-environments (TME), altering homeostasis and immune response in the extracellular matrix (ECM) of surrounding tissue. A potential factor that contributes to TME generation and ECM remodeling is the cytoskeleton-associated human...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD026072 | Pride
Cam Multiphoton microscopy Crc Collagen Ecm remodeling 
ProteomicsUnraveling the matrix: Proteomic profiling reveals stromal ECM dysregulation in severe early-onset fetal growth restriction
Severe, early-onset fetal growth restriction with absent or reversed end-diastolic umbilical artery velocities (FGRa/r) is marked by profound placental vascular insufficiency, yet the role of the villous stromal extracellular matrix (ECM) in this pathology remains poorly defined. Here, we applied an...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD070632 | Pride
Proteomics Fetal growth restriction Pregnancy Fibrosis Collagen Extracellular matrix Placenta 
ProteomicsExtracellular matrix proteome remodeling with substrate stiffness
Extracellular matrix proteomic profiling Mass spectrometry characterization illustrated a reprogrammed proteome in response to matrix stiffness, including a core subset of 84 ECM-specific proteins, including various ECM regulators and tissue-associated ECM-related proteins. Further, we observe remod...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092971 | MassIVE
GenomicsFibroblast starvation activates ECM remodeling gene transcription and putative enhancers despite inducing quiescence [bruseq]
Fibroblast starvation activates ECM remodeling gene transcription and putative enhancers despite inducing quiescence [bruseq]
PRJNA1137061 | ENA
GenomicsFibroblast starvation activates ECM remodeling gene transcription and putative enhancers despite inducing quiescence [chipseq]
Fibroblast starvation activates ECM remodeling gene transcription and putative enhancers despite inducing quiescence [chipseq]
PRJNA1137060 | ENA
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