Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of human lung tissue from emphysema and control patients
Gene expression profiling of lung tissue from undiseased (NML), 'usual' emphysema (EML), and Alpha-1 Antitrypsin Deficiency-related emphysema (ADL).
ORGANISM(S): Homo sapiens 
2007-07-19 | E-GEOD-1122 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lung tissue from severe emphysema versus normal or mild emphysema human patients
Comparison of severely emphysematous tissue removed at lung volume reduction surgery to that of normal or mildly emphysematous lung tissue resected from smokers with nodules suspicious for lung cancer. Data obtained from the 18 patients with severe emphysema and 12 patients with mild/no emphysema. R...
ORGANISM(S): Homo sapiens 
2007-08-13 | E-GEOD-1650 | biostudies-arrayexpress
TranscriptomicsUpregulation of Expression of Matrix Metalloproteinases in Alveolar Macrophages of HIV1+ Smokers with Early Emphysema
HIV1+ smokers develop emphysema at an earlier age and with a higher incidence than HIV1- smokers. Based on the knowledge that human alveolar macrophages (AM) are capable of producing proteases that degrade extracellular matrix components, we hypothesized that upregulation of AM matrix metalloprotein...
ORGANISM(S): Homo sapiens 
2016-03-24 | E-GEOD-10038 | biostudies-arrayexpress
ProteomicsCELA1 and AAT deficient murine model proteome
Chymotrypsin-like elastase 1 (CELA1) is a serine protease that is neutralized by alpha-1 antitrypsin (AAT) and prevents emphysema in a murine antisense oligonucleotide model of AAT-deficient emphysema. We tested the role of CELA1 in emphysema development in this genetic model of AAT-deficiency follo...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-02-20 | MSV000091330 | MassIVE
TranscriptomicsA gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK.
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease consisting of emphysema, small airway obstruction, and/or chronic bronchitis that results in significant loss of lung function over time. METHODS: In order to gain insights into the molecular pathways underlying prog...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-27597 | biostudies-arrayexpress
ProteomicsFemale mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema
Paladin (Pald1, mKIAA1274 or x99384) was identified in screens for vascular-specific genes and is a putative phosphatase. We have demonstrated that paladin has a predominant vascular expression pattern and shifts from endothelial to mural cells during mouse development. We have now characterized the...
ORGANISM(S): Mus Musculus (mouse) 
2017-11-01 | PXD005625 | JPOST Repository
MetabolomicsAssociations between 69 Sphingolipids and Emphysema, Chronic Bronchitis, Exacerbations, and FEV1/FVC
Not available
ORGANISM(S): Homo sapiens 
ST000362 | MetabolomicsWorkbench
TranscriptomicsExpression data from the lungs of Scnn1b-Transgenic and wild-type mice
Airway mucus obstruction triggers macrophage activation and MMP12-dependent emphysema microarray expression profiling of lungs from Scnn1b-Tg mice to search for emphysema candidate genes
ORGANISM(S): Mus musculus 
2014-07-24 | E-GEOD-49373 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of lung tissues from patients with combined pulmonary fibrosis and emphysema
Combined pulmonary fibrosis and emphysema (CPFE) is characterized by upper-lobe emphysema combined with lower-lobe fibrosis and a high prevalence of pulmonary hypertension. The aim of this study was to measure and analyze gene expression profiles in the lungs of CPFE patients. The results showed tha...
ORGANISM(S): Homo sapiens 
2012-06-26 | E-GEOD-38934 | biostudies-arrayexpress
TranscriptomicsMolecular mechanisms of cigarette smoke-induced lung emphysema
Chronic obstructive pulmonary disease (COPD) is a complex pulmonary disorder primarily induced by cigarette smoking, and characterized by persistent airflow limitation. The mouse represents an important model for studying COPD pathologies such as lung emphysema. In this respect, a number of mechanis...
ORGANISM(S): Mus musculus 
2014-11-28 | E-MTAB-2756 | biostudies-arrayexpress
Sort   by:  
 Page size