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Appendicular skeletal growth and bone mass acquisition are controlled by a variety of growth factors, hormones, and mechanical forces in a dynamic process called endochondral ossification. In long bones, chondrocytes in the growth plate proliferate and undergo hypertrophy to drive bone lengthening a...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-22 | PXD055563 | Pride
Phlpp1 regulates endochondral ossification via the chondrocyte phospho-proteome
Mesenchymal cell-derived septoclasts resorb cartilage during endochondral ossification and fracture healing
Loss of Foxc1 and Foxc2 function in chondroprogenitor cells disrupts endochondral ossification.
A Transcriptional Hub for Endochondral ossification adn Fracture Repair.
Molecular Profiling of Failed Endochondral Ossification in Mucopolysaccharidosis VII
Mesenchymal cell-derived septoclasts resorb cartilage during endochondral ossification and fracture healing
ORGANISM(S): Mus musculus 
2021-12-11 | GSE154076 | GEO
Endochondral ossification (EO) is the natural route for the regeneration of large and mechanically challenged bone defects. Regeneration occurs via a fibrocartilagenous phase which turns into bone upon vascularization and the formation of a transient collagen type X extra cellular matrix. These two ...
ORGANISM(S): Homo sapiens 
Histone deacetylase inhibitors are efficacious epigenetic-based therapies for some cancers and neurological disorders; however, these drugs inhibit multiple Hdacs and have detrimental effects on the pre- and post-natal skeleton. To better understand how Hdac inhibitors affect the skeleton, we focus...
ORGANISM(S): Mus musculus 
Histone deacetylase inhibitors are efficacious epigenetic-based therapies for some cancers and neurological disorders; however, these drugs inhibit multiple Hdacs and have detrimental effects on the pre- and post-natal skeleton. To better understand how Hdac inhibitors affect the skeleton, we focus...
ORGANISM(S): Mus musculus 
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