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TranscriptomicsEpCAM overexpression prolongs proliferative capacity of primary human breast epithelial cells and supports hyperplastic growth
Background: The Epithelial Cell Adhesion Molecule (EpCAM) has been shown to be strongly expressed in human breast cancer and cancer stem cells and its overexpression has been supposed to support tumor progression and metastasis. However, effects of EpCAM overexpression on normal breast epithelial ce...
ORGANISM(S): Homo sapiens 
2013-06-20 | E-GEOD-37172 | biostudies-arrayexpress
TranscriptomicsEpCAM overexpression prolongs proliferative capacity of primary human breast epithelial cells and supports hyperplastic growth.
Introduction: The Epithelial Cell Adhesion Molecule (EpCAM) has been shown to be strongly expressed in human breast cancer and cancer stem cells and its overexpression has been supposed to support tumor progression and metastasis. However, effects of EpCAM overexpression on normal breast epithelial ...
ORGANISM(S): Homo sapiens 
2013-06-13 | E-GEOD-39071 | biostudies-arrayexpress
ProteomicsThe sequence-specific peptide-binding activity of the protein sulfide isomerase AGR2 directs its’ stable binding to the oncogenic receptor EpCAM
AGR2 is an oncogenic endoplasmic reticulum (ER)-resident protein disulfide isomerase. AGR2 protein has a relatively unique property for a chaperone in that it can bind sequence-specifically to a peptide motif (TTIYY). A synthetic TTIYY-containing peptide column can be used to affinity-purify AGR2 f...
ORGANISM(S): Escherichia coli 
2018-01-22 | PXD005782 | Pride
Human Hdx Agr2 Protein-protein interaction Epcam Lc-ms/ms 
TranscriptomicsExpression data from SP and non-SP sorted anti-EpCAM treated A549 cells
Targeted therapies against cancer stem cells, which are enriched in side populations (SP), involves interruption of Wnt-signalling. Furthermore, EpCAM is a SP marker and modulator of Wnt-signalling. Therefore, the effects of an anti-EpCAM treatment on SP-cells and WNT/β-catenin signalling was studi...
ORGANISM(S): Homo sapiens 
2012-08-07 | E-GEOD-31315 | biostudies-arrayexpress
TranscriptomicsExpression data from SP and non-SP sorted anti-EpCAM treated A2C12 cells
Targeted therapies against cancer stem cells which are enriched in side populations (SP) involves interruption of Wnt-signalling. Furthermore, EpCAM is a SP marker and modulator of Wnt-signalling. Therefore, the effects of an anti-EpCAM treatment on SP-cells and WNT/M-NM-2-catenin signalling was stu...
ORGANISM(S): Mus musculus 
2012-08-07 | E-GEOD-31246 | biostudies-arrayexpress
TranscriptomicsEpCAM expressing Hs578T cells
EpCAM is frequently overexpressed in human invasive breast cancer. We reported EpCAM overexpression to be an independent prognostic marker for poor overall survival in node-positive breast cancer. We used microarrays in order to investigate changes of the transcriptome on EpCAM gene overexpression i...
ORGANISM(S): Homo sapiens 
2010-12-02 | E-GEOD-25743 | biostudies-arrayexpress
TranscriptomicsExpression data from SP and non-SP sorted anti-EpCAM treated A2C12 and A549 cells compared to non-transgenic lung tissue
This SuperSeries is composed of the following subset Series: GSE31246: Expression data from SP and non-SP sorted anti-EpCAM treated A2C12 cells GSE31313: Expression data from anti-EpCAM treated and untreated SP cells compared to lung tissue GSE31315: Expression data from SP and non-SP sorted anti-Ep...
ORGANISM(S): Mus musculus 
2012-08-07 | E-GEOD-31317 | biostudies-arrayexpress
TranscriptomicsA Pooled RNAi Screening Strategy Reveals Novel Regulators for EpCAM
The cell surface receptor, Epithelial Cell Adhesion Molecule (EpCAM), is overexpressed in a variety of cancers and has been carefully examined for its functional role in carcinogenesis and its potential as a therapeutic target. However, little is known about the upstream molecular pathways that reg...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-32985 | biostudies-arrayexpress
ProteomicsPreclinical targeted therapy for retinoblastoma using EpCAM Aptamer siRNA chimeras
siRNAs have played a major role in cancer drug discovery, but their potential is hampered due to off-target effects. Thus, delivery systems like RNA aptamers have been used to enhance the specific delivery of these siRNAs to cancer stem cells. We report the efficacy of three different EpCAM aptamer ...
ORGANISM(S): Homo sapiens (Human) 
2022-03-02 | PXD008221 | Pride
Retinoblastoma Targeted delivery Cancer stem cells Epcam 
TranscriptomicsEpCAM knock-down in FaDu head and neck carcinoma cells
Epithelial cell adhesion molecule EpCAM is a single transmembrane protein, which is involved in numerous cellular processes including cell adhesion, proliferation, maintenance of stemness of embryonic cells and progenitors, migration, and invasion. Activation of signal transduction by EpCAM is warra...
ORGANISM(S): Homo sapiens 
2012-04-13 | E-GEOD-37257 | biostudies-arrayexpress
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