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ProteomicsSecretome profiling of canine mammary tumor cells reveals AGR2-mediated regulation of protein secretion
Canine mammary tumors (CMTs) in intact female dogs serve as a valuable natural model for understanding human cancers. Our previous findings identified the overexpression of Anterior Gradient 2 (AGR2) in CMT tissues compared to normal mammary glands, highlighting its association with CMT progression....
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2024-06-16 | PXD047008 | Pride
Canine mammary tumor (cmt) Secretome Label-free quantification Anterior gradient 2 (agr2) 
ProteomicsThe sequence-specific peptide-binding activity of the protein sulfide isomerase AGR2 directs its’ stable binding to the oncogenic receptor EpCAM
AGR2 is an oncogenic endoplasmic reticulum (ER)-resident protein disulfide isomerase. AGR2 protein has a relatively unique property for a chaperone in that it can bind sequence-specifically to a peptide motif (TTIYY). A synthetic TTIYY-containing peptide column can be used to affinity-purify AGR2 f...
ORGANISM(S): Escherichia coli 
2018-01-22 | PXD005782 | Pride
Human Hdx Agr2 Protein-protein interaction Epcam Lc-ms/ms 
ProteomicsHuman colorectal cancer cell lines with manipulated AGR2 expression SWATH MS
SWATH MS analysis of colorectal adenocarcinoma derived paired cellular model, namely SW480 derived from a primary tumour and SW620 derived from the tumour´s lymph node metastasis. The whole proteome spectra were analysed to assess the changes caused by the manipulation of AGR2 expression. AGR2, a pr...
ORGANISM(S): Homo sapiens (Human) 
2025-04-23 | PXD053085 | Pride
Sw480 Colorectal adenocarcinoma Sw620 Agr2 Swath ms 
TranscriptomicsThe protein disulfide isomerase AGR2 is essential for the production of intestinal mucus
Protein disulfide isomerases (PDIs) aid protein folding and assembly by catalyzing formation and shuffling of cysteine disulfide bonds in the endoplasmic reticulum (ER). Many members of the PDI family are expressed in mammals but the roles of specific PDIs in vivo are poorly understood. A recent hom...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-12503 | biostudies-arrayexpress
TranscriptomicsGenes regulated by AGR2 in pancreatic cancer cell lines FA6 and MiaPaCa2
We and others have shown that AGR2 is frequently upregulated during the development of pancreatic cancer. We used microarray to look at the target genes regulated by AGR2 in pancreatic cancer cell lines FA6 and MiaPaCa2. Keywords: gene knock-down, overexpression We transiently down-regulated AGR2 e...
ORGANISM(S): Homo sapiens 
2013-07-28 | E-GEOD-12513 | biostudies-arrayexpress
ProteomicsOxonium ion guided analysis of quantitative proteomics data reveals site-specific O-glycosylation of anterior gradient protein 2 (AGR2)
Developments in mass spectrometry (MS)-based analyses of glycoproteins have been important to study changes in glycosylation related to disease. Recently, the characteristic pattern of oxonium ions in glycopeptide fragmentation spectra had been used to assign different sets of glycopeptides. In part...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025805 | Pride
Glycoproteomics  tmt labeling  oxonium ion  lc−ms/ms  o-glycosylation  colorectal cancer  agr2 
TranscriptomicsGene expression profile of the stomach from an AGR2 null mouse
The in vivo function of AGR2 was examined by generating an AGR2 null mouse. The mice died prematurely due to hyperplasia and dysplasia of the glandular stomach. Gene expression profiling was performed to compare differences in transcription between wild-type and null AGR2 mice. Female AGR2 wild-typ...
ORGANISM(S): Mus musculus 
2012-12-01 | E-GEOD-40062 | biostudies-arrayexpress
ProteomicsIdentification of AGR2 interacting proteins in H1299 cells using SILAC quantification
LC-MS/MS analysis with SILAC quantification to identify proteins interacting with AGR2 protein in H1299 lung cancer cells
ORGANISM(S): Homo sapiens (Human) 
2022-01-03 | PXD012687 | Pride
Anterior gradient protein 2  protein-protein interactions  protein disulfide isomerase  lc-ms  silac 
ProteomicsIdentification of AGR2 interacting proteins in T47D cells using label-free quantification
LC-MS/MS analysis with label-free quantification to identify proteins interacting with AGR2 protein in T47D breast cancer cells
ORGANISM(S): Homo sapiens (Human) 
2022-01-03 | PXD012690 | Pride
Anterior gradient protein 2  protein-protein interactions  protein disulfide isomerase  lc-ms  label-free quatification 
ProteomicsAnterior Gradient protein 2 is a marker of tumor aggressiveness in breast cancer and favors chemotherapy-induced senescence escape.
Among the different chemotherapies available, genotoxic drugs are widely used. In response to these drugs, particularly doxorubicin, tumor cells can enter into senescence. Chemotherapy-induced senescence (CIS) is a complex response. Long described as a definitive arrest of cell proliferation, we and...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028073 | Pride
Chemotherapy Agr2 Senescence 
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