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DNA extracted from human A549 cell lines and a mouse cell line established from a KPC (KrasG12D/+/p53 fl/fl/LSL- Rosa26LSL-Cas9-EGFP) tumor mouse model. We mixed eight different fractions (0/100, 15/85, 30/70, 45/55, 60/40, 75/25, 90/10, and 100/0) of human and mouse DNA. The mixture was hybridized...
ORGANISM(S): Homo sapiens 
Creation and Validation of the First Infinium DNA Methylation Array for the Human Imprintome [blood_epic]
This dataset comprises genome-wide DNA methylation profiles generated using Illumina Infinium methylation arrays (EPIC and EPICv2) to assess the effects of DNA methyltransferase 1 inhibitor (DNMT1i) treatment on CpG methylation patterns in high-grade serous ovarian carcinoma (HGSOC) models. The stud...
ORGANISM(S): Homo sapiens 
We simultaneously extracted DNA and protein from >200 single fibres per participant (7 males, 5 females) to directly compare methylome and proteome profiles of Type I and Type II human skeletal muscle fibres. Using the EPICv2 array and LC-MS/MS, we identified 5,689 robust DMRs (FDR <0.001) and 338 D...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD066393 | Pride
Accounting for differences between Infinium MethylationEPIC v2 and v1 in DNA methylation-based tools
The recently launched Illumina Infinium MethylationEPIC v2.0 (EPICv2), successor of MethylationEPIC v1.0 (EPICv1), retains a majority of probes in EPICv1, while expanding coverage of regulatory elements. The concordance between the two EPIC versions in DNA methylation-based tools has not yet been in...
ORGANISM(S): Homo sapiens 
2025-06-12 | GSE286313 | GEO
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