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ProteomicsEpitope and Paratope Mapping of TNFα/Infliximab complex by cross-linking mass spectrometry and integrative modeling reveals high level of interaction specificity
Mass spectrometry (MS) has become one of the core technologies to study protein structures, protein-ligand and protein-protein interactions. Chemical cross-linking combined with mass spectrometry (XL-MS) is quickly spreading over different biochemistry laboratories for the continuous increase of its...
ORGANISM(S): Escherichia coli 
2024-02-27 | PXD043347 | Pride
Cross-linking mass spectrometry  monoclonal antibodies  integrative modeling  epitope/paratope mapping 
UnknownMapping paratope on antithrombotic antibody 6B4 to epitope on platelet glycoprotein Ibalpha via molecular dynamic simulations.
Not available
S-EPMC3408434 | biostudies-literature
ProteomicsMass Spectrometry-Driven Epitope Mapping: Application of Diethylpyrocarbonate Covalent Labeling for the Immunotherapeutic Target Programmed Cell Death Protein 1
Monoclonal antibodies (mAbs) have transformed cancer immunotherapy, with anti-PD1 mAbs playing a pivotal role. This study introduces diethylpyrocarbonate covalent labeling-mass spectrometry (DEPC CL-MS) as a rapid and sensitive technique for epitope mapping of PD1, a critical target in mAb developme...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-26 | MSV000096536 | MassIVE
ProteomicsEpitope and paratope mapping of a SUMO-remnant antibody using cross-linking mass spectrometry and molecular docking
The small ubiquitin-like modifier (SUMO) is an important post-translational modification that regulates the function of various proteins essential for DNA damage repair, genome integrity and cell homeostasis. To identify protein SUMOylation effectively, an enrichment step is necessary, often require...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2025-02-19 | PXD055077 | Pride
Antibody Cross-linking Mass spectrometry Molecular docking Paratope mapping Sumo 
ProteomicsEpitope and paratope mapping of a SUMO-remnant antibody using cross-linking mass spectrometry and molecular docking
The small ubiquitin-like modifier (SUMO) is an important post-translational modification that regulates the function of various proteins essential for DNA damage repair, genome integrity and cell homeostasis. To identify protein SUMOylation effectively, an enrichment step is necessary, often require...
ORGANISM(S): Oryctolagus sp. 'Rabbit_OD' 
2025-02-19 | PXD055085 | Pride
Antibody Cross-linking Mass spectrometry Molecular docking Paratope mapping Sumo 
ProteomicsEpitope and paratope mapping of a SUMO-remnant antibody using cross-linking mass spectrometry and molecular docking
The small ubiquitin-like modifier (SUMO) is an important post-translational modification that regulates the function of various proteins essential for DNA damage repair, genome integrity and cell homeostasis. To identify protein SUMOylation effectively, an enrichment step is necessary, often require...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2025-02-19 | PXD060724 | Pride
Antibody Cross-linking Mass spectrometry Molecular docking Paratope mapping Sumo 
UnknownEpitope and Paratope Mapping of PD-1/Nivolumab by Mass Spectrometry-Based Hydrogen-Deuterium Exchange, Cross-linking, and Molecular Docking.
Not available
S-EPMC7501946 | biostudies-literature
UnknownMapping Potential Antigenic Drift Sites (PADS) on SARS-CoV-2 Spike in Continuous Epitope-Paratope Space.
Not available
S-EPMC8202428 | biostudies-literature
UnknownEpitope mapping via in vitro deep mutational scanning methods and its applications.
Not available
S-EPMC11783119 | biostudies-literature
UnknownImmunoglobulin constant regions provide stabilization to the paratope and enforce epitope specificity.
Not available
S-EPMC11215335 | biostudies-literature
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