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MetabolomicsClostridium bolteae suppresses Enterobacteriaceae expansion and restores gut microbiome homeostasis via disrupting siderophore-mediated iron acquisition

Intestinal inflammation and the related gut microbiome dysbiosis are becoming prevalent worldwide. Overgrowth of Enterobacteriaceae exacerbates intestinal inflammation and gut microbiome dysbiosis. Enterobacteriaceae secrets siderophore to acquire iron and survive in the iron-limited gut. Therefo...

2026-01-03 | MTBLS13592 | MetaboLights
MetabolomicsVitamin D deficiency disrupts a host–microbiota bile acid axis in aged mice to drive Faecalibaculum rodentium expansion and intestinal epithelial barrier dysfunction
This study investigated how vitamin D deficiency alters the fecal metabolome and bile acid metabolism in mice and evaluated the contribution of Faecalibaculum rodentium bile salt hydrolase activity to intestinal epithelial barrier dysfunction. Two complementary mouse experiments were included. In th...
2026-08-07 | MTBLS15279 | MetaboLights
ProteomicsSpatially Resolved Proteomics via Tissue Expansion
Spatially resolved proteomics is an emerging approach, however, it remains technically challenging due to the complexity of the tissue microsampling techniques and mass spectrometry analysis of nanoscale specimen volumes. Here, we describe an expansion proteomics method ProteomEx, a combination of t...
ORGANISM(S): Mus <genus> 
2022-11-04 | PXD037950 |
TranscriptomicsDe novo sequencing and analysis of the Panax ginseng transcriptome in the leaf-expansion period
In order to analyze the transcriptome of ginseng root during leaf-expansion period and discover the genes during development, a cDNA sample was prepared from the leaf-expansion period of ginseng root and sequenced using the Illumina sequencing platform.The transcriptomic sequencing technology was se...
ORGANISM(S): Panax ginseng 
2013-06-15 | E-MTAB-974 | biostudies-arrayexpress
Genomics
FSIS NARMS Diversity Expansion Genome sequencing
PRJNA701285 | ENA
TranscriptomicsTranscription profiling of human BM-MSC expanded from p2 until p10 and monitored by FACS, proliferation kinetics and differentiation ability
hBM-MSC were expanded from p2 until p10 and monitored by FACS, proliferation kinetics and differentiation ability;µA analysis were performed p2/p5 (n=10)and p5/p10 (n=5) to examine if the genetic background of hBM-MSC is changeing during their high-grade expansion;
ORGANISM(S): Homo sapiens 
2007-06-09 | E-MARS-6 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human BM-MSC expanded from p2 until p10 and monitored by FACS, proliferation kinetics and differentiation ability
hBM-MSC were expanded from p2 until p10 and monitored by FACS, proliferation kinetics and differentiation ability;µA analysis were performed p2/p5 (n=10)and p5/p10 (n=5) to examine if the genetic background of hBM-MSC is changeing during their high-grade expansion;
ORGANISM(S): Homo sapiens 
2007-06-09 | E-MARS-5 | biostudies-arrayexpress
TranscriptomicsFibronectin regulates Wnt7a signaling and satellite cell expansion
The influence of the extracellular matrix (ECM) within the stem cell niche remains poorly understood. We found that Syndecan-4 (Sdc4) and Frizzled-7 (Fzd7) form a coreceptor complex in satellite cells and that binding of the ECM glycoprotein Fibronectin (FN) to Sdc4 stimulates the ability of Wnt7a t...
ORGANISM(S): Mus musculus 
2014-07-11 | E-GEOD-59272 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human islets after in vitro expansion.
Pancreatic islet transplantation as a cure for type 1 diabetes (T1D) cannot be scaled up due to a scarcity of human pancreas donors. In vitro expansion of beta cells from mature human pancreatic islets provides an alternative source of insulin-producing cells. The exact nature of the expanded cells ...
ORGANISM(S): Homo sapiens 
2009-08-07 | E-GEOD-15543 | biostudies-arrayexpress
TranscriptomicsABP1-regulated gene expression in etiolated Arabidopsis seedlings
The AUXIN BINDING PROTEIN 1 (ABP1) is an essential plant protein involved in the control of growth and development all along the plant life. This protein was initially identified on its capacity to bind the phytohormone auxin. Binding of auxin to ABP1 was shown to enhance cell expansion of leaf cell...
ORGANISM(S): Arabidopsis thaliana 
2015-04-07 | E-GEOD-46196 | biostudies-arrayexpress
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