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TranscriptomicsExpression data from mesothelial (LP9) and mesothelioma cells (HMESO) inhibited for extracellular-regulated kinase (ERK) 1, 2, or 5
Extracellular-regulated kinases (ERK1/2 and 5) are known to play important roles in growth and drug resistance of various cancers. Here we show roles of inhibition of ERK1, ERK2, or ERK5 on gene expression profiles of epithelioid malignant mesothelioma (MM) cells (HMESO). Untransfected human mesothe...
ORGANISM(S): Homo sapiens 
2010-05-08 | E-GEOD-21750 | biostudies-arrayexpress
GenomicsGenome wide extracellular signal-regulated kinase (ERK) pathway components interaction with human genome
Several recent studies, including ours, show that most components of signal transduction cascades including the extracellular signal-regulated protein kinase (ERK), that once were thought to act predominantly in cytoplasm, are in fact recruited to chromatin and are integral components of transcript...
ORGANISM(S): Homo sapiens 
2015-08-01 | E-GEOD-65323 | biostudies-arrayexpress
TranscriptomicsGenomic Collaboration of Estrogen Receptor-α and ERK2 in Regulating Gene and Proliferation Programs
The nuclear hormone receptor, estrogen receptor-alpha (ERα), and MAP kinases both play key roles in hormone-dependent cancers, yet their interplay and the integration of their signaling inputs remain poorly understood. In these studies, we document that estrogen-occupied ERα activates and interact...
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-24592 | biostudies-arrayexpress
TranscriptomicsAberrant ERK signaling causes resistance to EGFR kinase inhibitors
The clinical efficacy of EGFR kinase inhibitors is limited by the development of drug resistance. The irreversible EGFR kinase inhibitor WZ4002 is effective against the most common mechanism of drug resistance mediated by the EGFR T790M mutation. Here we show that in multiple complementary models ha...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-37699 | biostudies-arrayexpress
ProteomicsStructural Analysis of Hippocampal Kinase Signal Transduction
Kinases are a major clinical target for human diseases. Identifying the proteins that interact with kinases in vivo will provide information on unreported substrates and will potentially lead to more specific methods for therapeutic kinase regulation. Here, endogenous immunoprecipitations of evolu...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2018-05-23 | MSV000082390 | MassIVE
GenomicsGenome wide extracellular signal-regulated kinase (ERK) pathway components interaction with human genome
Several recent studies, including ours, show that most components of signal transduction cascades including the extracellular signal-regulated protein kinase (ERK), that once were thought to act predominantly in cytoplasm, are in fact recruited to chromatin and are integral components of transcripti...
ORGANISM(S): Homo sapiens 
2016-08-18 | GSE65323 | GEO
ProteomicsTAP-ERK2-K52R MS analysis of 1D gel bands
MS analysis of 1D gel bands from TAP-ERK2-K52R immunoprecipitation experiments
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000088047 | MassIVE
TranscriptomicsTranscription profiling by array of left ventricle tissues from rat with overexpression of constitutively active upstream kinase mitogen-activated protein kinase kinase 3b (MKK3bE) and wild-type p38? in the heart
Mitogen-activated protein kinases (MAPKs) regulate cardiomyocyte growth and apoptosis in response to extracellular stimulation, but the downstream effectors that mediate their pathophysiological effects remain poorly understood. We determined the targets and role of p38 MAPK in the heart in vivo by ...
ORGANISM(S): Rattus norvegicus 
2009-04-25 | E-GEOD-3866 | biostudies-arrayexpress
UnknownMechanisms of extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway in depressive disorder.
Not available
S-EPMC4146087 | biostudies-literature
UnknownDevelopment of extracellular signal-regulated kinase inhibitors.
Not available
S-EPMC2835149 | biostudies-literature
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