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MetabolomicsQuantitative Metabolomic Dataset of Avian Eye Lenses

Metabolomics is a powerful set of methods that uses analytical techniques to identify and quantify metabolites in biological samples, providing a snapshot of the metabolic state of a biological system. In medicine, metabolomics can help diagnose diseases, reveal molecular basis of a disease, and ...

2023-06-30 | MTBLS7739 | MetaboLights
MetabolomicsQuantitative metabolomic analysis of changes in the lens and aqueous humor under development of age-related nuclear cataract

INTRODUCTION: Metabolites are essential for the proper functioning of the eye lens, they either enter the lens from the aqueous humor (AH), or are synthesized in the lens epithelium. Antioxidants, osmolytes and UV filters are especially important for the lens protection, and thei...

2022-11-07 | MTBLS740 | MetaboLights
ProteomicsEye proteome of Drosophila melanogaster
We report the proteome composition of the Drosophila eye – a compound organ that is highly enriched in membrane proteins. The fly eye is a popular model to study the physiology of vision by means of genetic, pharmacological, and dietary interference.While the eye transcriptome and development-relate...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2024-08-09 | PXD044845 | Pride
Eye Gelc-ms/ms Proteomics Drosophila melanogaster 
TranscriptomicsTranscription profiling of Drosophila eye antennal imaginal disc expressing either activated Ras or secreted Spitz
We have used microarrays to identify genes expressed and required for the second mitotic wave (SMW) during eye development. Eye discs expressing Spitz under the control of GMR Gal4 have no SMW as Spitz promotes G1 arrest, ectopic differentiation also occures. To control for the ectopic differentiati...
ORGANISM(S): Drosophila melanogaster 
2008-06-14 | E-GEOD-6300 | biostudies-arrayexpress
GenomicsGenome-wide binding of the homeodomain transcription factor Sine oculis (So) in the Drosophila eye imaginal disc
We report genome-wide binding of the highly conserved TF Sine oculis (So), which is necessary for Drosophila eye development and has few previously known direct transcriptional targets. Our data identify novel putative targets of So-mediated regulation, including genes involved in multiple aspects o...
ORGANISM(S): Drosophila melanogaster 
2014-03-17 | E-GEOD-52943 | biostudies-arrayexpress
GenomicsDiscovery of Transcription Factors and Regulatory Regions Driving In Vivo Tumor Development by ATAC-seq and FAIRE-seq Open Chromatin Profiling
Genomic enhancers regulate spatio-temporal gene expression by recruiting specific combinations of transcription factors (TFs). When TFs are bound to active regulatory regions, they displace canonical nucleosomes, making these regions biochemically detectable as nucleosome-depleted regions or accessi...
ORGANISM(S): Drosophila melanogaster 
2015-02-13 | E-GEOD-59078 | biostudies-arrayexpress
Genomicseye development
eye development in a basal panarthropod
PRJEB29741 | ENA
TranscriptomicsMeis1 coordinates a network of genes implicated in eye development and microphthalmia
Microphthalmos is a rare congenital anomaly characterized by reduced eye size and visual deficits of variable degrees. Sporadic and hereditary microphthalmos has been associated to heterozygous mutations in genes fundamental for eye development. Yet, many cases are idiopathic or await the identifica...
ORGANISM(S): Mus musculus 
2015-08-27 | E-GEOD-62786 | biostudies-arrayexpress
MetabolomicsCars2-Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2.
Targeting transcriptional regulatory complexes represents a promising strategy for activating thermogenic fat and treating obesity. In this study, we focused on identifying critical, specific metabolic pathways enriched during brown adipocyte differentiation. Through analysis of metabolomics and RNA...
2026-03-24 | MTBLS12237 | MetaboLights
GenomicsIdentification of lens-regulated genes driving anterior eye development and eye size.
Identification of lens-regulated genes driving anterior eye development and eye size.
PRJNA1196933 | ENA
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