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GenomicsNext Generation Sequencing of Newly excysted juveniles, Juveniles and Adult Fasciola hepatica
Next Generation Sequencing of Newly excysted juveniles, Juveniles and Adult Fasciola hepatica
PRJNA776863 | ENA
ProteomicsStudy of the migration of Fasciola hepatica juveniles across the intestinal barrier of the host by quantitative proteomics in an ex vivo model
The project presents the set-up of an ex vivo model coupled with quantitative SWATH-MS proteomics to study the early events following the passage of Fasciola hepatica Newly Excysted Juveniles (NEJ) though the host’s intestinal wall, assessing the proteomic changes in their surface (tegument) and som...
ORGANISM(S): Fasciola hepatica (Liver fluke) 
2022-08-31 | PXD033945 | Pride
Fasciola hepatica  newly excysted juveniles  gut passage  swath-ms  quantitative proteomics  differential expression 
ProteomicsThe host factor: proteomic comparison of excretion/1 secretion products in Fasciola hepatica newly excysted juveniles (NEJ) derived from Lymnaea viatrix or Pseudosuccinea columella
The characteristics of parasitic infections are often tied to host behavior. Although most studies have investigated definitive hosts, intermediate hosts can also play a role in shaping the distribution and accumulation of parasites. This is particularly relevant in larval stages, where intermediate...
ORGANISM(S): Fasciola hepatica (Liver fluke) 
2019-04-30 | PXD011991 | Pride
Parasite-host interaction Fasciola hepatica Intermediate host Secretome 
GenomicsNext Generation Sequencing of Newly excysted juveniles, Juveniles and Adult Fasciola hepatica
Purpose: The miRnome of the liver fluke, Fasciola hepatica, has historically been assembled with limited omic's resources using specific life stages. The goals of this study is to quanity the known and published miRNAs and determine novel miRNAs across three intra-mammlian life stages. Methods: Tota...
ORGANISM(S): Fasciola hepatica 
2022-05-31 | GSE186948 | GEO
ProteomicsPROTEOMIC ANALYSIS OF EXTRACELLULAR VESICLES FROM FASCIOLA HEPATICA HATCHING EGGS AND JUVENILES IN CULTURE
The identification of extracellular vesicles (EVs) in Fasciola hepatica has provided a new way to understand parasite-host communication. Most of the studies on EVs have focused on the adult stage of F. hepatica, but recently, the presence of EVs from different developmental stages has been reported...
ORGANISM(S): Fasciola hepatica (Liver fluke) 
2022-08-12 | PXD033086 | Pride
Extracellular vesicles  fasciola hepatica juveniles  fasciola hepatica eggs  helminth proteomics 
ProteomicsProteomic analysis of Fasciola hepatica somatic proteome and secretome
Background The parasite Fasciola hepatica infects a broad range of mammals with impunity. Following ingestion of parasites (metacercariae) by the host, newly excysted juveniles (NEJ) emerge from their cysts, rapidly penetrate the duodenal wall and migrate to the liver. Successful infection takes j...
ORGANISM(S): Fasciola hepatica (Liver fluke) 
2018-03-26 | PXD007255 | Pride
Fasciola hepatica Metacercariae Somatic proteome Nej Secretome Es proteins 
ProteomicsProteomics analyses of immature (21 day post infection) Fasciola hepatica
The major pathogenesis associated with Fasciola hepatica infection results from the extensive tissue damage caused by the tunnelling and feeding activity of immature flukes during their migration, growth and development in the liver. This is compounded by the pathology caused by host innate and adap...
ORGANISM(S): Fasciola hepatica (Liver fluke) 
2021-09-09 | PXD021221 | Pride
Fasciola hepatica Lc-ms-ms Growth Liver Somatic proteome Secretome 
GenomicsFasciola hepatica
The miRNome of Fasciola hepatica juveniles endorse the existence of a reduced set of highly divergent miRNAs in parasitic flatworms.
PRJNA277065 | ENA
ProteomicsProteomics coupled with in vitro model to study the early crosstalk occurring between newly excysted juveniles of Fasciola hepatica and host intestinal cells
Here, we develop a new in vitro model replicating the first interaction of FhNEJ with mouse primary small intestinal epithelial cells (MPSIEC). FhNEJ and MPSIEC were incubated for 3 hours and protein extracts (tegument and soma for FhNEJ and membrane and cytosol for MPSIEC) were subjected to quantit...
ORGANISM(S): Fasciola hepatica (Liver fluke) 
2022-09-20 | PXD033952 | Pride
Fasciola hepatica  newly excysted juveniles  swath-ms  quantitative proteomics  differential expression  host-parasite interaction 
ProteomicsIn vitro host-parasite models combined with proteomics reveal cell type-specific responses of early-migrating Fasciola hepatica juveniles
The project employs two complementary in vitro models combined with quantitative proteomics to study host-parasite interactions involving Fasciola hepatica newly excysted juveniles. The single cell type (SiCT) model uses SWATH-MS to analyse interactions with mesothelial and hepatic stellate cells, w...
ORGANISM(S): Mus musculus (Mouse) Fasciola hepatica (Liver fluke) 
2026-03-02 | PXD066004 | Pride
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