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ProteomicsProteomic analysis of Fasciola hepatica somatic proteome and secretome
Background The parasite Fasciola hepatica infects a broad range of mammals with impunity. Following ingestion of parasites (metacercariae) by the host, newly excysted juveniles (NEJ) emerge from their cysts, rapidly penetrate the duodenal wall and migrate to the liver. Successful infection takes j...
ORGANISM(S): Fasciola hepatica (Liver fluke) 
2018-03-26 | PXD007255 | Pride
Fasciola hepatica Metacercariae Somatic proteome Nej Secretome Es proteins 
ProteomicsThe host factor: proteomic comparison of excretion/1 secretion products in Fasciola hepatica newly excysted juveniles (NEJ) derived from Lymnaea viatrix or Pseudosuccinea columella
The characteristics of parasitic infections are often tied to host behavior. Although most studies have investigated definitive hosts, intermediate hosts can also play a role in shaping the distribution and accumulation of parasites. This is particularly relevant in larval stages, where intermediate...
ORGANISM(S): Fasciola hepatica (Liver fluke) 
2019-04-30 | PXD011991 | Pride
Parasite-host interaction Fasciola hepatica Intermediate host Secretome 
GenomicsHigh-throughput sequence data of ChIP performed with anti-SMARCAD1 (ASNA) or anti-CBP actibodies.
Histone acetylation and nucleosome remodeling play a pivotal role in transcriptional regulation. While histone acetylase and ATP-dependent chromatin remodeling activities have been well characterized, how the two activities are coordinated remains to be uncovered. We discovered ATP-dependent histone...
ORGANISM(S): Drosophila melanogaster 
2016-03-17 | E-GEOD-72666 | biostudies-arrayexpress
UnknownDataset supporting the proteomic differences found between excretion/secretion products from two isolates of Fasciola hepatica newly excysted juveniles (NEJ) derived from different snail hosts.
Not available
S-EPMC6661421 | biostudies-literature
ProteomicsTime-resolved analysis reveals rapid dynamics and broad scope of the CBP/p300 acetylome
The acetyltransferases CBP and p300 are multifunctional transcriptional co-activators; however, their acetylation targets, site-specific acetylation kinetics, and function in proteome regulation are incompletely understood. We combined quantitative proteomics with novel CBP/p300-specific catalytic i...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
MSV000095981 | MassIVE
ProteomicsCrosslinking mass spectrometry of the p300 catalytic core complexed with the nucleosome
p300 is a histone acetyltransferase that associates with crucial biological processes. p300 acetylates all four histones in the nucleosome, a basic unit of chromatin, and alters chromatin structure and dynamics. In this study, we performed structural and biochemical analysis to understand the nucleo...
ORGANISM(S): Homo Sapiens (human) 
2022-06-29 | PXD033804 | JPOST Repository
OtherData for: Short-chain fatty acids activate acetyltransferase p300/CBP
The short-chain fatty acids (SCFAs) acetate, propionate, and butyrate are produced in large quantities by the gut microbiome and contribute to a wide array of physiological processes. While the underlying mechanisms are largely unknown, many effects of SCFAs have been traced to changes in epigenetic...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-07-12 | MSV000087800 | MassIVE
GenomicsDorsal dependent CBP binding on a genome wide scale
We find a high concordance between the binding of the Drosophila transcription factor Dorsal and the co-activator CBP during early embryogenesis. This relationship was furter examined by comparing CBP distribution in Drosophila embryos derived from wt and mutant flies lacking intranuclear Dorsal (gd...
ORGANISM(S): Drosophila melanogaster 
2012-06-28 | E-GEOD-34221 | biostudies-arrayexpress
UnknownIn vitro co-culture of <i>Fasciola hepatica</i> newly excysted juveniles (NEJs) with 3D HepG2 spheroids permits novel investigation of host-parasite interactions.
Not available
S-EPMC11938319 | biostudies-literature
TranscriptomicsTranscription profiling of mouse C2AS12 cells infected with (1) wt p300 + tTA, (2) p300deltaTAZ2 +tTA, (3) wt p300 +tTA +doxycycline to define the transcriptional network regulated by ectopic expression of the transcriptional co-activator protein, p300 and define its role in promoting muscle cell survival
The primary focus of these studies is to define the transcriptional network regulated by ectopic expression of the transcriptional co-activator protein, p300, in order to define its mechanism(s) of action in promoting muscle cell survival. Our laboratory has generated a murine C2-derived myoblast ce...
ORGANISM(S): Mus musculus 
2007-12-07 | E-GEOD-4224 | biostudies-arrayexpress
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