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MetabolomicsA Pathogen-Responsive Gene Cluster for Highly Modified Fatty Acids in Tomato
In response to biotic stress, plants produce suites of highly modified fatty acids that bear unusual chemical functionalities. Despite their chemical complexity and proposed roles in pathogen defense, little is known about the biosynthesis of decorated fatty acids in plants. Falcarindiol is a protot...
2022-01-17 | MTBLS1039 | MetaboLights
MetabolomicsFatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols
Fatty acid transport protein 4 (FATP4) is an acyl-CoA synthetase that is required for normal permeability barrier in mammalian skin. FATP4 (SLC27A4) mutations cause ichthyosis prematurity syndrome, a nonlethal disorder. In contrast, Fatp4-/- mice die neonatally from a defective barrier. H...
2021-07-15 | MTBLS1138 | MetaboLights
MetabolomicsGut Microbiota Regulates Serum Metabolites in Mice with Nonalcoholic Fatty Liver Disease via Gut Metabolites: Mechanisms Involving Branched-Chain Amino Acids and Unsaturated Fatty Acids

In recent years, nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease globally. Studies indicate that the gut-liver axis plays an important role in the occurrence and development of this disease. Our previous studies showed that the gut microbiota and gut meta...

2025-07-02 | MTBLS12668 | MetaboLights
MetabolomicsEffect of probiotics intervention on short chain fatty acids in irradiated mice

In order to study the effect of probiotic intervention on short-chain fatty acids in irradiated mice, we collected feces, blood, and brain tissues from irradiated mice. The content of short-chain fatty acids was determined by High Performance Liquid Chromatography-mass spectrum. Further investiga...

2026-09-28 | MTBLS15754 | MetaboLights
MetabolomicsUntargeted Metabolomics Analysis Reveals Aberrant Long-Chain Fatty Acids Metabolism in Relapsing-Remitting Multiple Sclerosisublication title

Background: Growing evidence indicates significant alterations in fatty acid metabolism in patients with relapsing-remitting multiple sclerosis (RRMS). However, the metabolic status of long-chain fatty acids (LCFAs), including mono-unsaturated fatty acids (MUFAs) and poly-unsaturated fatty acids ...

2026-03-23 | MTBLS13949 | MetaboLights
MetabolomicsEssential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain

Omega-3 fatty acids (n-3 polyunsaturated fatty acids; n-3 PUFAs) are essential for the functional maturation of the brain. Westernization of dietary habits in both developed and developing countries is accompanied by a progressive reduction in dietary intake of n-3 PUFAs. Low maternal intake of n...

2020-11-03 | MTBLS1952 | MetaboLights
MetabolomicsEffect of transplantation of irradiated mouse feces on blood short chain fatty acids in recipient mice
In order to study the effect of transplantation of irradiated mouse feces on the short chain fatty acids in the blood of recipient mice, we used mobile phones to transplant the feces of donor mice from 1W to 4W after irradiation. After 2W of antibiotic intervention, fecal bacteria were transplanted ...
2026-09-28 | MTBLS15752 | MetaboLights
MetabolomicsOmega-3 polyunsaturated fatty acids modulate gut microbiota-derived 18β-glycyrrhetinic acid to alleviate type 1 diabetes mellitus

Background

Omega-3 polyunsaturated fatty acids (PUFAs) are known to protect against type 1 diabetes mellitus (T1DM), but how they act through the gut-islet axis is not fully understood. This study explored how Omega-3 PUFA-influenced gut microbiota and their metabolites help protect pancrea...

2026-06-13 | MTBLS13006 | MetaboLights
MetabolomicsOmega-3 polyunsaturated fatty acids modulate gut microbiota-derived 18β-glycyrrhetinic acid to alleviate type 1 diabetes mellitus

Background

Omega-3 polyunsaturated fatty acids (PUFAs) are known to protect against type 1 diabetes mellitus (T1DM), but how they act through the gut-islet axis is not fully understood. This study explored how Omega-3 PUFA-influenced gut microbiota and their metabolites help protect pancrea...

2026-06-13 | MTBLS13174 | MetaboLights
MetabolomicsAdipocyte-specific Zeb1 confers breast cancer progression by triggering the tumor-associated adipose microenvironment remodeling_Medium and long chain fatty acids

Upon penetrating the basement membrane, breast cancer cells directly interact with their surrounding adipose tissue, which forms a unique tumor-associated adipose microenvironment (TAME). However, the underlying mechanism involved in the regulation of lipid metabolic remodeling in the TAME remain...

2025-04-30 | MTBLS12290 | MetaboLights
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