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ProteomicsIGF-1 stimulated C2 skeletal myotube phosphoproteome
Skeletal muscle is known to adapt dynamically to changes in workload by regulatory processes of the phosphatidylinositide 3-kinase (PI3K)/Akt pathway. We performed a global quantitative phosphoproteomics analysis of contracting mouse C2 myotubes treated with insulin growth factor 1 (IGF-1) as contro...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-25 | PXD016721 | Pride
Silac Phospho-proteomics C2 Myotubes 
ProteomicsPhosphoproteomic analysis of induced neurons from patients with Huntington’s disease
Huntington’s disease (HD) is an inherited neurodegenerative disorder that is caused by CAG expansions in the huntingtin (HTT) gene. Modelling HD in the lab has proven challenging as rodent models poorly reproduce the disease process and cellular models fail to include age-dependent processes crucial...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD055857 | Pride
Induced neurons Huntington disease 
ProteomicsMutations in the postsynaptic signaling hub TNIK disrupts neuronal progenitor cells and immature neuronal function in human models of neurodevelopmental disease
Synaptic proteins, in particular those connected in large protein interaction networks at the postsynaptic site of glutamatergic neurons have been associated to a number of neurodevelopmental disorders. While their contribution to disease has been well documented in mature rodent synapses, their rol...
ORGANISM(S): Homo sapiens (Human) 
2024-03-26 | PXD035004 | Pride
Neurodevelopment Hipsc Signaling networks Disease Postsynaptic Signaling 
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