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TranscriptomicsDevelopment and Preclinical Efficacy of Novel Transforming Growth Factor-β1 (TGFβ1) siRNAs for Pulmonary Fibrosis
Idiopathic pulmonary fibrosis is a chronic devastating disease of unknown etiology. No therapy is currently available. A growing body of evidence supports the role of TGFβ1 as the major player in the pathogenesis of the disease. This study designed novel human- and mouse-specific siRNAs and siRNA/DN...
ORGANISM(S): Mus musculus 
2011-11-22 | E-GEOD-28122 | biostudies-arrayexpress
TranscriptomicsGene expression profiles based on Pulmonary Artery Pressures in Pulmonary Fibrosis
Pulmonary Hypertension (PH) is a frequent complication of Pulmonary Fibrosis (PF). PH can be seen in PF in the abscence of hypoxemia, irrespective of the degree of fibrosis. At the same time, a consistent number of patients with advanced PF never develop PH. The pathogenesis of PH secondary to PF re...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-24988 | biostudies-arrayexpress
TranscriptomicsSpatial transcriptomics (Visium, 10x Genomics) data for human Idiopathic Pulmonary Fibrosis (IPF) and control lung tissue
Visium (10x Genomics) spatially resolved transcriptomics data generated from normal and Idiopathic Pulmonary Fibrosis (IPF) lung parenchyma tissues collected from human donors. The fresh-frozen tissues that were analyzed were from four healthy control (HC) subjects and from four IPF patients. For ea...
ORGANISM(S): Homo sapiens 
2024-05-28 | E-MTAB-14121 | biostudies-arrayexpress
MetabolomicsTibetan medicine Shi-Wei-Gan-Ning-Pill (SWGNP) protect rats from ccl4 induced liver fibrosis.(Part I: Liver)
Not available
ORGANISM(S): Rattus norvegicus 
ST000993 | MetabolomicsWorkbench
TranscriptomicsRNA-seq of hepatic biopsies taken from patients with chronic liver disease presenting with different aetiologies (HCV, FLD) and fibrosis stages.
To determine gene signatures associated with advanced liver fibrosis, we undertook RNA-sequencing of liver biopsies from patients presenting with different aetiologies (HCV or FLD) and fibrosis stages (n=69 patients). This dataset is part of the TransQST collection.
ORGANISM(S): Homo sapiens 
2018-07-28 | E-MTAB-6863 | biostudies-arrayexpress
TranscriptomicsBleomycin induces molecular changes directly relevant to idiopathic pulmonary fibrosis: A model for “active” disease
Genomic profiling of RNA from cultured human fibroblasts of donor samples in the 10-14th passage was carried out to determine expression changes in the fibroblasts of individual with different degrees of pulmonary fibrosis. Donors consisted of individuals with rapid progressing pulmonary fibrosis, s...
ORGANISM(S): Homo sapiens 
2013-04-10 | E-GEOD-44723 | biostudies-arrayexpress
GenomicsSuper-Enhancer-mediated Control of Liver Fibrosis by BET Bromodomain Proteins
Here, we investigate the role of enhancers in myofibroblasts, a cell type that dominates the pathogenesis and progression of tissue fibrosis. We reveal that bromodomain and extra-terminal family members (BETs), an important group of epigenetic readers, are critical for super-enhancer-mediated pro-fi...
ORGANISM(S): Homo sapiens 
2015-12-11 | E-GEOD-58680 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Cystic Fibrosis cell line and a control cell line
comparison of expression profiles between a cystic fibrosis cell line and a control cell line
ORGANISM(S): Homo sapiens 
2007-09-26 | E-MEXP-980 | biostudies-arrayexpress
TranscriptomicsInhibition of Peripheral Serotonin Activates Hepatic AMPK and Reduces Monocyte-Derived Liver Macrophages, Ameliorating Obesity-Associated Fibrosis
Monocyte-derived liver macrophages are critical in the pathogenesis of metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis, but their recruitment mechanisms remain unclear. Serotonin (5-hydroxytryptamine, 5HT) is a conserved monoamine synthesized by tryptophan hydroxylase (Tph...
ORGANISM(S): Mus musculus 
2025-10-30 | E-MTAB-15760 | biostudies-arrayexpress
TranscriptomicsExpression data of cystic fibrosis and non-cystic fibrosis airway cell lines under oxidative stress
CF's physiopathology is poorly explained by the mutation alone. The oxydative stress could be a major factor of this illness . Study its impact on transcriptome's CF cell line could be ameliorate our understanding of the evolution of cystic fibrosis. we used microarray technology to evaluate under ...
ORGANISM(S): Homo sapiens 
2012-08-02 | E-GEOD-39843 | biostudies-arrayexpress
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