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ProteomicsPTENε, a new isoform of PTEN, suppresses tumor metastasis through filopodia formation regulation.
PTEN is frequently mutated in a wide range of malignancies. Beyond suppressing tumorigenesis, PTEN is involved in multiple biological processes, and the complexity of PTEN function is partially attributed to PTEN family members including PTENα and PTENβ. Here, we report the identification of PTENε (...
ORGANISM(S): Homo sapiens (Human) 
2021-01-11 | PXD022245 | Pride
Alternative initiation/filopodia formation/ptenε/pten isoform/metastasis. 
ProteomicsA Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia...
3xFLAG-IPs from HEK293T cell lysates expressing 3xFLAG-bait or 3xFLAG-control. Trypsin Digestion
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-04-09 | MSV000079100 | MassIVE
UnknownDopamine transporter is enriched in filopodia and induces filopodia formation.
Not available
S-EPMC4593718 | biostudies-literature
TranscriptomicsTranscription profiling of bone marrow derived mast cells from WASP negative and wild type mice to investigate the role of WASP in Kit signalling
The pleiotropic RTK Kit can provide cytoskeletal signals that define cell shape, positioning and migration, but the underlying mechanisms are less well understood. Here we provide evidence that Kit signals through WASP (Wiskott-Aldrich Syndrome Protein), the central hematopoietic actin nucleation- ...
ORGANISM(S): Mus musculus 
2009-08-29 | E-MEXP-2282 | biostudies-arrayexpress
UnknownChiral growth of adherent filopodia.
Not available
S-EPMC10541518 | biostudies-literature
UnknownSecreted exosomes induce filopodia formation.
Not available
S-EPMC12803517 | biostudies-literature
UnknownSecreted exosomes induce filopodia formation.
Not available
S-EPMC11952364 | biostudies-literature
ProteomicsA Nanobody inhibitor of Fascin-1 actin-bundling activity and filopodia formation
Fascin-1 mediated actin-bundling activity is central to the generation of plasma membrane protrusions required for cell migration. Dysregulation of cellular protrusions is observed in metastatic cancers, where they are required for increased invasiveness, and this is often correlated with overexpres...
ORGANISM(S): Homo sapiens (Human) 
2024-03-25 | PXD038713 | Pride
Fascin-1 Hydrogen deuterium exchange Nanobody Hdx 
UnknownFilopodia numbers impact chemotactic migration speed.
Not available
S-EPMC12258711 | biostudies-literature
TranscriptomicsNeural crest cells bulldoze through the microenvironment using water channel proteins to stabilize filopodia
Neural crest migration requires cells to move through dense extracellular matrix and mesoderm to reach targets throughout the vertebrate embryo. Here, we use high-resolution microscopy, computational modeling, and in vitro and in vivo cell invasion assays to investigate the function of Aquaporin-1 (...
ORGANISM(S): Gallus gallus 
2019-12-16 | GSE121131 | GEO
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