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MetabolomicsMetabolomic Analysis of Fission Yeast at the Onset of Nitrogen Starvation
Microorganisms naturally respond to changes in nutritional conditions by adjusting their morphology and physiology. The cellular response of the fission yeast S. pombe to nitrogen starvation has been extensively studied. Here, we report time course metabolomic analysis during one hour immediately af...
2013-11-26 | MTBLS67 | MetaboLights
MetabolomicsThe putative ceramide-conjugation protein Cwh43 regulates G0 quiescence, nutrient metabolism and lipid homeostasis in fission yeast (Metabolome assay)
Cellular nutrient states control whether cells proliferate, or whether they enter or exit quiescence. Here, we report characterizations of fission yeast temperature-sensitive (ts) mutants of the evolutionarily conserved transmembrane protein, Cwh43, and explore its relevance to utilization of glucos...
2018-08-17 | MTBLS577 | MetaboLights
MetabolomicsSpecific biomarkers for stochastic division patterns and starvation-induced quiescence under limited glucose levels in fission yeast
Glucose as a source of energy is centrally important to our understanding of life. We investigated the cell division-quiescence behavior of the fission yeast Schizosaccharomyces pombe under a wide range of glucose concentrations (0-111 mM). The mode of S. pombe cell division under a microfluidic per...
2017-07-06 | MTBLS316 | MetaboLights
MetabolomicsThe putative ceramide-conjugation protein Cwh43 regulates G0 quiescence, nutrient metabolism and lipid homeostasis in fission yeast (Lipidome assay)
Cellular nutrient states control whether cells proliferate, or whether they enter or exit quiescence. Here, we report characterizations of fission yeast temperature-sensitive (ts) mutants of the evolutionarily conserved transmembrane protein, Cwh43, and explore its relevance to utilization of glucos...
2018-08-21 | MTBLS578 | MetaboLights
GenomicsMediator promotes CENP-A incorporation at fission yeast centromeres
This SuperSeries is composed of the following subset Series: GSE32310: Transcriptome analysis of mediator Med20 mutant and dcr1 mutant in S.pombe GSE35524: Mediator promotes CENP-A incorporation at fission yeast centromeres [ChIP-seq] Refer to individual Series
ORGANISM(S): Schizosaccharomyces pombe 
2012-11-06 | E-GEOD-35527 | biostudies-arrayexpress
TranscriptomicsHairpin RNA induces secondary small interfering RNA synthesis and silencing in trans in fission yeast
We provide evidence of the generation of Rdp1-mediated secondary siRNAs in vivo in fission yeast. Secondly, we show that the presence of Ago1-associated siRNAs does not guarantee robust silencing. We obtained sequences from gel purified small RNAs of wt and rdp1delta fission yeast cells and FLAG-ago...
ORGANISM(S): Schizosaccharomyces pombe 
2010-02-15 | E-GEOD-20330 | biostudies-arrayexpress
TranscriptomicsHistone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast.
In budding yeast, Set2 catalyzes di- and trimethylation of H3K36 (H3K36me2 and H3K36me3) via an interaction between its SRI domain and C-terminal repeats of RNA polymerase II (Pol2) phosphorylated at Ser2 and Ser5 (CTD-S2,5-P). H3K36me2 recruits the Rpd3S histone deacetylase complex to repress crypt...
ORGANISM(S): Schizosaccharomyces pombe 
2016-02-04 | E-GEOD-66821 | biostudies-arrayexpress
TranscriptomicsDistinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.
Rheb, a ras-like small GTPase conserved from human to yeast, controls Tor kinase and plays a central role in regulation of cell growth depending on extracellular conditions. Fission yeast Rheb regulates amino acid uptake as well as response to nitrogen starvation. In this study we generated two muta...
ORGANISM(S): Schizosaccharomyces pombe 
2009-09-28 | E-GEOD-14626 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of 968xY0036 fission yeast recombinant library
We generated the first recombinant strain library for fission yeast and conducted an RNA-seq based QTL study of the coding, non-coding, and antisense transcriptomes. We cross the lab strain 968 with the lab strain Y0036 to generate segregant. We used RNA-seq for both expression profiling and gentoyp...
ORGANISM(S): Schizosaccharomyces pombe 
2014-12-04 | E-MTAB-2640 | biostudies-arrayexpress
TranscriptomicsExpression data from fission yeast Schizosaccharomyces pombe under nitrosative stress
Nitric oxide being a versatile molecule inside biological systems, from being both a cell signaling molecule to a potent stress agent, has significant effect in the transcriptional response in fission yeast. We have used fission yeast microarrays to identify cellular targets of Nitric Oxide (NO) and...
ORGANISM(S): Schizosaccharomyces pombe 
2015-01-30 | E-GEOD-50899 | biostudies-arrayexpress
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