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TranscriptomicsCRC samples for FOLFOX therapy prediction
The aim of this study is to identify responders to FOLFOX therapy by applying the Random Forests (RF) algorithm to gene expression data. Eighty-three unresectable colorectal cancer (CRC) patients including 42 responders and 41 non-responders were divided into training (54 patients) and test (29 pati...
ORGANISM(S): Homo sapiens 
2011-11-21 | E-GEOD-28702 | biostudies-arrayexpress
ProteomicsProteomic profiling of chemotherapy responses in FOLFOX-resistant colorectal cancer cells
we aim to compare the difference of chemotherapy responses between FOLFOX-resistant and wild type colorectal cancer cells for suggesting novel treatment targets.
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD042136 | Pride
Colorectal cancer Folfox Chemoresistance 
TranscriptomicsRNA-seq of cancer cell lines upon administration of FOLFOX or FOLFIRI at different time points
This experiment is aimed at studying the effect of two different chemotherapies (FOLFOX and FOLFIRI) on colorectal cancer cell lines (HCT116 and HT29) at different time points. Two early time points (8h and 16h) are used to evaluate the acute response, while a late time point (two weeks, LT) is used...
ORGANISM(S): Homo sapiens 
2023-09-01 | E-MTAB-12948 | biostudies-arrayexpress
TranscriptomicsRNA-seq of HCT116 cells upon administration of FOLFOX or FOLFIRI at time points with or without ULK1 inhibitor
This experiment is aimed at studying the effect of two different chemotherapies (FOLFOX and FOLFIRI) and their interaction with a ULK1 inhibitor on HCT116 colorectal cancer cell line.
ORGANISM(S): Homo sapiens 
2023-09-01 | E-MTAB-12947 | biostudies-arrayexpress
ProteomicsPlasma Proteomic Characterization of Colorectal Cancer Patients with FOLFOX Chemotherapy
Colorectal Cancer (CRC) is one of most common cancers in the world and a main treatment in postoperative chemotherapy is oxaliplatin and fluorouracil (FOLFOX), But the effect is different among CRC patients. In this study, LC-MS/MS strategy was used to profile the plasma proteome in FOLFOX benefit a...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD044201 | Pride
Human plasma proteome  sisprot  lc-ms/ms  random forest  prm validation 
ProteomicsGlobal proteome changes in liver tissue 6 weeks after FOLFOX treatment of colorectal cancer liver metastases.
Study: Oxaliplatin-based chemotherapy for colorectal liver metastasis is associated with sinusoidal injury of liver parenchyma and may result in increased morbidity after liver surgery. Preclinical and human liver parenchyma studies have proposed several pathways of oxaliplatin-induced injury, but t...
ORGANISM(S): Homo sapiens (Human) 
2016-12-14 | PXD001889 | Pride
Innate immune response Recovery of liver injury Minichromosome maintenance complex 
TranscriptomicsSingle cell RNA-seq analysis of cancer cell lines upon administration of FOLFOX or FOLFIRI at different time points
This experiment is aimed at studying the effect of two different chemotherapies (FOLFOX and FOLFIRI) on colorectal cancer cell lines (HCT116 and HT29) at different time points. Two early time points (8h and 16h) are used to evaluate the acute response, while a late time point (two weeks, LT) is use...
ORGANISM(S): Homo sapiens 
2023-09-01 | E-MTAB-12949 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-seq analysis of cancer cell lines upon administration of FOLFOX or FOLFIRI at different time points
This experiment is aimed at studying the effect of two different chemotherapies (FOLFOX and FOLFIRI) on gene expression of HCT116 colorectal cancer cell line at different time points. Two early time points (8h and 16h) are used to evaluate the acute response, while a late time point (two weeks, LT) ...
ORGANISM(S): Homo sapiens 
2023-09-01 | E-MTAB-12950 | biostudies-arrayexpress
TranscriptomicsSingle cell tracking of expressed barcodes in cancer cell lines upon administration of FOLFOX or FOLFIRI at different time points
This experiment is aimed at studying the effect of two different chemotherapies (FOLFOX and FOLFIRI) on HCT116 colorectal cancer cell line on clonal heterogeneity. One early time point (8h) is used to evaluate the initial population, while a late time point (two weeks, LT) is used to evaluate the lo...
ORGANISM(S): Homo sapiens 
2023-09-01 | E-MTAB-12951 | biostudies-arrayexpress
TranscriptomicsSingle cell GET-seq analysis of cancer cell lines upon administration of FOLFOX or FOLFIRI at different time points
This experiment is aimed at studying the effect of two different chemotherapies (FOLFOX and FOLFIRI) on chromatin accessibility of HCT116 colorectal cancer cell line at different time points. Two early time points (8h and 16h) are used to evaluate the acute response, while a late time point (two wee...
ORGANISM(S): Homo sapiens 
2023-09-01 | E-MTAB-12952 | biostudies-arrayexpress
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