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TranscriptomicsTranscription profiling of rat testis aafter acute antibody mediated FSH suppression
To unravel the genes that underpin the effects of FSH on spermatogenesis, testicular gene expression was compared in juvenile rats after FSH suppression to littermate controls. Based on existing data, it is apparent that the dominant function of FSH shifts between 9 and 18 day postpartum (dpp) duri...
ORGANISM(S): Rattus norvegicus 
2008-06-11 | E-GEOD-10293 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of bovine oocytes with high developmental competence obtained from FSH-stimulated animals
The objective of the study was to analyze the impact of various lenght FSH withdrawal period (coasting) after the last FSH injection on transcriptome changes in in vivo bovine oocytes at the GV stage. Oocytes were collected from super-stimulated animals after 20, 44, 68 and 92 hours of coasting. For...
ORGANISM(S): Bos taurus 
2013-06-21 | E-GEOD-38345 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat and mouse granulosa cells infected with adenoviral vectors expressing two FOXO1 mutants reveals FSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cells
The forkhead box transcription factor FOXO1 is highly expressed in granulosa cells of growing follicles but is down-regulated by FSH in culture or by LH-induced luteinization in vivo. To analyze the function of FOXO1, we infected rat and mouse granulosa cells with adenoviral vectors expressing two F...
ORGANISM(S): Rattus norvegicus 
2009-04-25 | E-GEOD-15727 | biostudies-arrayexpress
TranscriptomicsEffects of FSH knockdown on gene expression
see Super Series Summary Gene expression profiles of Drosophila S2-DRSC FSH knockdown cells were generated by Illumna RNA sequencing and compared to profiles derived from control cells (eGFP knockdown).
ORGANISM(S): Drosophila melanogaster 
2013-02-06 | E-GEOD-43180 | biostudies-arrayexpress
TranscriptomicsFoxo1/3 depletion in granulosa cells reveals novel mechanisms controlling follicle growth and death and endocrine regulation of pituitary FSH.
The Foxo transcription factors regulate multiple cellular functions. Foxo1 and Foxo3 are highly expressed in granulosa cells of ovarian follicles. Selective depletion of the Foxo1 and Foxo3 genes in granulosa cells revealed a novel ovarian-pituitary endocrine feedback loop characterized by: 1) undet...
ORGANISM(S): Mus musculus 
2013-02-16 | E-GEOD-35593 | biostudies-arrayexpress
TranscriptomicsIdentification of gonadotropin-responsive genes in fish testis
In all vertebrates, the dual function of testis (production of sexual steroids and production of gametes) is mainly regulated by two gonadotropic pituitary hormones, FSH and LH. However, in fish the biological activities of the two hormones are not still clearly delineated and moreover, their molecu...
ORGANISM(S): Oncorhynchus mykiss 
2012-10-22 | E-GEOD-39465 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of granulosa cells after conventional vs long FSH-induced superstimulation in cattle
Conventional Superstimulation (group 1) vs. Long Superstimulation (group 3) A genome-wide bovine oligo-microarray was used to compare the gene expression of granulosa cells collected from ovarian follicles after differing durations of the growing phase induced by exogenous FSH treatment. Cows were g...
ORGANISM(S): Bos taurus 
2016-08-01 | E-GEOD-80289 | biostudies-arrayexpress
TranscriptomicsImpact of G protein versus beta-arrestin-dependent signal transduction at the FSH receptor (affy_fsh_human)
affy_fsh_human - affy_fsh_human - - G protein-coupled receptors (GPCR) are centrally involved in most physiological processes and are a major drug targets. They transduce extracellular signals inside the cells through at least two different mechanisms: i) the classical coupling to heterotrimeric G p...
ORGANISM(S): Homo sapiens 
2011-11-25 | E-GEOD-21982 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of FSH response in bovine cumulus cells
Study the effect of recombinant human FSH supplementation in the in vitro maturation medium for an incubation of 6 hrs on the transcriptomics of bovine cumulus cells. 3 biological replicates of cumulus cells derived from cumulus oocyte complexes (COCs) supplemented with FSH (CC-FSH) vs. cumulus cell...
ORGANISM(S): Bos taurus 
2015-07-01 | E-GEOD-67970 | biostudies-arrayexpress
GenomicsGeneration of chromatin maps for ASH1 and FSH applying ChIP-seq
see Super Series Summary Cross-linked chromatin derived from Drosophila S2-DRSC cells was immunoprecipitated using antibodies targeting ASH1 and FSH. Precipitated chromatin was sequenced applying Illumina sequencing.
ORGANISM(S): Drosophila melanogaster 
2013-02-06 | E-GEOD-36404 | biostudies-arrayexpress
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