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ProteomicsHeteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP Type C
Neurodegenerative diseases are characterised by the abnormal filamentous assembly of specific proteins in the central nervous system1. Human genetic studies established a causal role for protein assembly in neurodegeneration2. However, the underlying molecular mechanisms remain largely unknown, whic...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055345 | Pride
Frontotemporal dementia Neurodegenerative disease Tdp-43 and tmem106b 
UnknownHeteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP type C.
Not available
S-EPMC11485244 | biostudies-literature
UnknownCombined Pathologies in FTLD-TDP Types A and C.
Not available
S-EPMC6019001 | biostudies-literature
ProteomicsVCP loss of function in neurons recapitulates FTLD-TDP pathology
Dominant mutations in unrelated genes cause fronto-temporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) and include VCP, which is associated with multisystem proteinopathy (MSP). Conditional inactivation of VCP in postnatal forebrain neurons (VCP cKO) caused cortical brain atrophy, neurona...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-06 | PXD026685 | Pride
Transcriptomic Vcp/p97 Proteomic Fronto-temporal lobar degeneration 
ProteomicsAmyloid fibrils in disease FTLD-TDP are composed of TMEM106B, rather than TDP-43
FTLD is the third most common neurodegenerative condition, following only Alzheimer's and Parkinson's diseases. FTLD typically presents in 45-64-year-olds with behavioral changes or progressive decline of language skills. The subtype FTLD-TDP is characterized by certain clinical symptoms and patholo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-22 | MSV000088430 | MassIVE
UnknownAnatomical Progression of Neuropathology in FTLD-TDP Type C and Linkage to Annexin A11.
Not available
S-EPMC12704552 | biostudies-literature
TranscriptomicsExpression Profiling of Caenorabditis elegans tdp-1 loss-of-function mutant
Transactive response DNA-binding protein of 43 kDa (TDP-43), a heterogeneous nuclear ribonucleoprotein (hnRNP) with diverse activities, is a common denominator in several neurodegenerative disorders including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Orthologs...
ORGANISM(S): Caenorhabditis elegans 
2012-02-21 | E-GEOD-34113 | biostudies-arrayexpress
TranscriptomicsTargeted RNA-seq of FTLD-TDP brain samples
UNC13A features a cryptic exon which is expressed upon loss of nuclear TDP-43. Here, we perform targeted RNA-seq on RNA extracted from 10 FTLD-TDP brain samples, and four control samples, enriching for the cryptic exon via nested PCR. Each FTLD-TDP sample is heterozygous for rs12973192. There are t...
ORGANISM(S): Homo sapiens 
2022-02-28 | E-MTAB-10237 | biostudies-arrayexpress
UnknownAntibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD-TDP subtypes.
Not available
S-EPMC7547034 | biostudies-literature
UnknownShared brain transcriptomic signature in TDP-43 type A FTLD patients with or without GRN mutations.
Not available
S-EPMC9337811 | biostudies-literature
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