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MetabolomicsMetabolic profiling of Candida clinical isolates of different species and infection sources

Candida species are the most common cause of opportunistic fungal infections. Rapid identification and novel approaches for the characterization of these fungi are of great interest to improve the diagnosis and the knowledge about their pathogenic properties. This study aimed to characte...

2024-07-09 | MTBLS1978 | MetaboLights
ProteomicsIn-depth evaluation of the acetylome in major human fungal pathogens elucidates the essential role of lysine acetylation in regulation of fungal pathogenicity
Fungal pathogens cause deadly diseases in living organisms. Numerous studies suggest that lysine acetylation is a critical regulator in pathogenic fungi, but an in-depth and cross-species analysis of the acetylome in major pathogenic fungi is lacking, and our knowledge of the mechanism of acetylatio...
ORGANISM(S): Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 
2019-04-29 | PXD010354 | Pride
Cryptococcus neoformans Virulence Protein posttranslational modification Human fungal pathogens Acetylation 
ProteomicsFungal extracellular vesicles are recoverable across variable ultracentrifugation speeds but display species-specific profiles of sedimentation
Extracellular vesicles (EVs) are central components of fungal biology, yet their isolation commonly relies on ultracentrifugation schemes originally developed for mammalian systems. In Cryptococcus, most EVs carry the capsular polysaccharide glucuronoxylomannan (GXM), raising the possibility that ve...
ORGANISM(S): Cryptococcus neoformans RCT29 
2026-06-29 | PXD076414 | Pride
Fungal extracellular  vesicles  ultracentrifugation  profiles 
ProteomicsCryptococcus neoformans proteins during fungal-macrophage interaction
Cryptococcus neoformans interactions with murine macrophages are critical for disease. In this project we analyzed fungal proteins which were co-purified with murine host proteins after interaction. H99 C. neoformans was opsonized with mAb 18B7 and addedd to murine macrophages. Then murine cells wer...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD024951 | Pride
Host-pathogen interactions Cryptococcus neoformans Fungi 
ProteomicsBioactive natural product peptide discovery in fungal secretoms using PepSAVI-MS
Fungal secondary metabolites represent a rich and largely untapped source for bioactive molecules, including peptides with substantial structural diversity and pharmacological potential. As methods proceed to take a deep dive into fungal genomes, complimentary methods to identify bioactive component...
ORGANISM(S): Ustilago maydis virus P4 
2018-02-19 | PXD006931 | Pride
Peptidomics Mass spectrometry Fungal secretome analysis Bioactive peptides 
UnknownEasy Proteomics Sample Preparation: Technical Repeatability and Workflow Optimization Across 8 Biological Matrices in a New Core Facility Setting.
Not available
S-EPMC12576925 | biostudies-literature
ProteomicsMetaproteomic Profiling of Functional Changes Driven by Gut Fungal Colonization
Gut microbiome modulates the host immune development, yet the functional contribution of gut fungi remains elusive. We previously showed that mice colonized only with fungi displayed allergic features and fecal metabolite profiles similar to germ-free mice. To gain insights into the functional chang...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-28 | PXD019355 | Pride
Gut fungi Early-life gut microbiome Lfq and tmt proteomics Gnotobiotic mice 
ProteomicsComparative genomics reveals high biological diversity and specific adaptations in the fungal genus Aspergillus
The project compares the genomes of multiple Aspergillus species. In particular, the genes involved in the degradation of plant-derived biomass have been analyzed. As well, the extracellular proteins produced by the fungi during the utilization of sugar beet pulp and wheat bran were examined by LC-M...
ORGANISM(S): Aspergillus wentii Aspergillus zonatus Aspergillus aculeatus ATCC 16872 Aspergillus tubingensis Aspergillus carbonarius ITEM 5010 Aspergillus versicolor Aspergillus foetidus var. acidus Aspergillus brasiliensis Aspergillus sydowii 
2018-10-26 | PXD005563 | Pride
Extracellular proteins Biomass degradation Aspergilli Lc-ms/ms 
ProteomicsUnbalanced roles of fungal aggressiveness and host genetic background in the establishment of the Fusarium head blight in bread wheat
Fungal effectors are key determinants of disease development, promoting pathogen growth and spreading in plant tissues. In the wheat/Fusarium graminearum (Fg) interaction determining the Fusarium Head Blight disease (FHB), the molecular bases of Fg aggressiveness remain widely unknown. The aim of th...
ORGANISM(S): Fusarium graminearum Triticum aestivum (Wheat) 
2020-01-13 | PXD015139 | Pride
Fungal aggressiveness Proteins Fusarium graminearum Fusarium head blight Wheat 
ProteomicsModifications of fungal membrane proteins profile under pathogenicity induction: a proteomic analysis of Botrytis cinerea membranome.
Botrytis cinerea is a model phytopathogenic fungus that infects more than 200 different relevant crops, thus being classified among the top ten fungal plant diseases. B. cinerea exhibits a wide arsenal of tools to infect plant tissues. Most of these factors are related to signal transduction cascade...
ORGANISM(S): Botryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea) Capsaspora owczarzaki 
2016-07-11 | PXD003099 | Pride
Botritys cinerea Proteomics Membranome Phytopathogenicity 
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