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MetabolomicsAberrant L-Fucose accumulation and increased core fucosylation are metabolic liabilities in mesenchymal glioblastoma (Stem cell and cell line assays)

Glioblastoma (GBM) is a common and deadly form of brain tumor in adults. Dysregulated metabolism in GBM offers an opportunity to deploy metabolic interventions as precise therapeutic strategies. To identify the molecular drivers and the modalities by which different molecular subgroups of GBM exp...

2022-11-08 | MTBLS4708 | MetaboLights
MetabolomicsAberrant L-Fucose accumulation and increased core fucosylation are metabolic liabilities in mesenchymal glioblastoma (Xenograft assays)

Glioblastoma (GBM) is a common and deadly form of brain tumor in adults. Dysregulated metabolism in GBM offers an opportunity to deploy metabolic interventions as precise therapeutic strategies. To identify the molecular drivers and the modalities by which different molecular subgroups of GBM exp...

2022-11-08 | MTBLS730 | MetaboLights
TranscriptomicsTranscription profling of glioblastoma stem-like (GS) cell lines, conventional glioma cell lines and primary tumors
We compared a large panel of human glioblastoma stem-like (GS) cell lines, corresponding primary tumors and conventional glioma cell lines to identify cell lines that preserve the transcriptome of human glioblastomas most closely, thereby allowing identification of shared therapeutic targets. We us...
ORGANISM(S): Homo sapiens 
2011-02-12 | E-GEOD-23806 | biostudies-arrayexpress
ProteomicsAdherent and Spheroid Glioblastoma Proteomics
Dendritic cell (DC)-based immunotherapy against glioblastoma multiforme is a novel treatment hope. Glioblastoma stem-like cells are, however, potentially causing immunoresistance. Glioblastoma cells cultured as gliomaspheres show a stem-like phenotype as opposed to classical adherent culture. They a...
ORGANISM(S): Homo sapiens (Human) 
2019-04-15 | PXD008244 | Pride
Dendritic cell Immunotherapy Antigen source Gliomasphere Quantitative proteomics Glioblastoma multiforme 
TranscriptomicsTranscription profiling of human glioma cell lines reveals CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and expression profiles
We cultured tumor cells from 22 GBM under medium conditions favoring the growth of neural stem cells. 11 out of 15 primary GBM contained a significant CD133+ subpopulation that comprised cells showing all hallmarks of neural stem cells. Cell lines derived from these CD133+ GBM showed a neurosphere-l...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-7181 | biostudies-arrayexpress
TranscriptomicsGlioblastoma microvesicles transport RNA and proteins
Glioblastoma tumour cells release microvesicles (exosomes) containing mRNA, miRNA and angiogenic proteins. These microvesicles are taken up by normal host cells, such as brain microvascular endothelial cells. By incorporating an mRNA for a reporter protein into these microvesicles, we demonstrate th...
ORGANISM(S): Homo sapiens 
2008-11-15 | E-GEOD-13470 | biostudies-arrayexpress
TranscriptomicsGBM_SC_retinoic acid_gene_expression
This study compared the gene expression change of glioblastoma stem-like cells before and after retinoic acid treatment Glioblastoma neurospheres 10627 and 20913 were treated with retinoic acid for 8h and 48h and compared with control
ORGANISM(S): Homo sapiens 
2011-04-06 | E-GEOD-21336 | biostudies-arrayexpress
TranscriptomicsGenomic analyses reveal miR-137 broad impact on genes associated with malignant transformation and neuronal differentiation in glioblastoma cells
miR-137 plays critical roles in the nervous system and tumor development. An increase in its expression is required for neuronal differentiation while its reduction is implicated in gliomagenesis. To evaluate the potential of miR-137 in glioblastoma therapy, we conducted genome-wide target mapping i...
ORGANISM(S): Homo sapiens 
2014-02-11 | E-GEOD-53220 | biostudies-arrayexpress
TranscriptomicsMolecular analysis of glioblastoma stem cell-like spheroid cultures identifies novel tumor-relevant genes
This SuperSeries is composed of the following subset Series: GSE14818: Gene expression analysis of glioblastoma spheroid cultures I GSE14819: Array CGH analysis of glioblastoma serum grown adherent cultures GSE14820: Array CGH analysis of glioblastoma cell lines GSE14821: Array CGH analysis of singl...
ORGANISM(S): Homo sapiens 
2010-02-12 | E-GEOD-14824 | biostudies-arrayexpress
TranscriptomicsGenome-wide CRISPR-Cas9 screens reveal loss of redundancy between PKMYT1 and WEE1 in Glioblastoma stem-like cells
To identify new therapeutic targets for Glioblastoma (GBM), we performed genome-wide CRISPR-Cas9 "knockout" (KO) screens in patient-derived GBM stem-like cells (GSCs) and human neural stem/progenitors (NSCs), non-neoplastic stem cell controls, for genes required for their in vitro growth. ...
ORGANISM(S): Homo sapiens 
2016-02-15 | E-GEOD-70038 | biostudies-arrayexpress
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