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MetabolomicsMetabolite profiling of Arabidopsis mutants of enzymes of lower glycolysis
We have previously shown that in Arabidopsis the three enzymes of lower glycolysis phosphoglycerate mutase (PGAM), enolase and pyruvate kinase form a complex which play an important role in co-sub-cellar localization the mitochondria to the chloroplast. Given that their metabolites of these mutants,...
2022-10-10 | MTBLS4066 | MetaboLights
ProteomicsDown-regulation of Rab 5C-dependent Endocytosis and Glycolysis in Cisplatin-resistant Ovarian Cancer Cell Lines
Drug resistance poses a major challenge to ovarian cancer treatment. Understanding mechanisms of drug resistance is important for finding new therapeutic targets. In the present work, a cisplatin-resistant ovarian cancer cell line A2780-DR was established with a resistance index of 6.64. The cellula...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080724 | MassIVE
TranscriptomicsCombinatorial targeting of glycolysis and oxidative phosphorylation suppresses tumor growth and metastases.
The Warburg effect, consisting of increased glucose uptake and glycolysis, provides metabolic energy as well as cellular building blocks for tumor growth. Inhibition of the Warburg effect with 2-deoxyglucose (2DG) has been explored in clinical trials with limited efficacy. Blockage of glycolysis can...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-16816 | biostudies-arrayexpress
TranscriptomicsRepression of genes for stimulators of glycolysis
The overall aim of the present work was to identify MTG16 functions in leukemia cells. Alterations in quantity of the MTG16 co-repressor might affect gene regulation and cell metabolism in malignant cells. Differentiated cells secure energy for cellular homeostasis largely by mitochondrial oxidation...
ORGANISM(S): Homo sapiens 
2012-12-04 | E-GEOD-42682 | biostudies-arrayexpress
TranscriptomicsHTCC1062 glucose versus no carbon log phase
The primary goal of this experiment is to examine the transcription profiles of HTCC1062 when grown in the presence or absence of D-glucose (30uM final concentration). Experiment confirmed activity of predicted glycolysis operon. Three biological replicates of HTCC1062 grown on glucose (30uM final c...
ORGANISM(S): Candidatus Pelagibacter ubique HTCC1062 
2010-05-16 | E-GEOD-14974 | biostudies-arrayexpress
TranscriptomicsZinc finger nuclease knockouts of human ADP-glucokinase
Zinc finger nucleases (ZFN) are powerful tools for editing genes in cells. Here we use ZFNs to interrogate the biological function of human ADPGK, which encodes an ADP-dependent glucokinase (ADPGK), in tumour cell lines. The hypothesis tested is that ADPGK utilises ADP to phosphorylate glucose under...
ORGANISM(S): Homo sapiens 
2012-07-19 | E-GEOD-39497 | biostudies-arrayexpress
MetabolomicsHif1α-Dependent Uncoupling Of Glycolysis Suppresses Tumor Cell Proliferation
Hypoxia-inducible factor-1α (HIF1α) attenuates mitochondrial activity while promoting glycolysis. Paradoxically, it remains unknown why lower glycolysis is compromised in human clear cell renal cell carcinomas (ccRCC), in which HIF1α acts a tumor suppressor by inhibiting cell autonomous proliferatio...
2024-03-15 | MTBLS8901 | MetaboLights
MetabolomicsMyeloid PFKFB3-mediated glycolysis promotes kidney fibrosis
Excessive renal fibrosis is a common pathology in progressive chronic kidney diseases. Inflammatory injury and aberrant repair processes contribute to the development of kidney fibrosis. Myeloid cells, particularly monocytes/macrophages, play a crucial role in kidney fibrosis by releasing their proi...
2024-03-12 | MTBLS8278 | MetaboLights
TranscriptomicsGene Dosage, Mainly 3q Amplification, Deregulates a Quarter of Genes in Cervical Cancer: It Induces Glycolysis, Anaphase-dependent Proteasome Proteolysis, and Low Survival
The contribution of copy number (CN)-altered genes in cervical carcinogenesis is unknown owing to a lack of correlation with gene expression. We mapped CN-altered genes in 31 cervical cancers (CCs), and investigated the expression of 21,000 genes in 55 CCs using microarrays. Biological processes ass...
ORGANISM(S): Homo sapiens 
2015-06-04 | E-GEOD-52903 | biostudies-arrayexpress
Proteomicsglycolysis protein-protein interaction
Arabidopsis glycolysis were overexperssed at plant cell culture to catch the protein-protein interaction in vivo.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-09-16 | PXD020588 | Pride
Protein-proteinin teraction Ap-ms Glycolysis 
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