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MetabolomicsLC- MS based untargeted metabolomic analysis of exsome-derived lung graft

A total of 50 mg of the same anatomical region of the lung graft(Syn group, N = 3; CR group, N = 9) was added to a 2 mL centrifuge tube to perform the untargeted metabolic analysis, Each QC sample is of the same volume as the test samples and is processed and detected using the same methods as th...

2026-09-18 | MTBLS14797 | MetaboLights
MetabolomicsPrevention of acute graft-versus-host disease via single-dose administration of bioengineered extracellular vesicles
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for various hematological and immunologic diseases, but acute graft-versus-host disease (aGVHD) remains a major cause of morbidity and mortality. We previously discovered in patients and murine models that higher le...
2026-09-11 | MTBLS15633 | MetaboLights
MetabolomicsMetabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites (Cohort 1)

Despite improvement in clinical management, allogeneic hematopoietic stem cell transplantation (HSCT) is still hampered by high morbidity and mortality rates, mainly due to Graft versus host disease (GvHD). Recently, it has been demonstrated that the allogeneic immune response might be influenced...

2019-11-06 | MTBLS204 | MetaboLights
MetabolomicsMetabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites (Cohort 2)

Despite improvement in clinical management, allogeneic hematopoietic stem cell transplantation (HSCT) is still hampered by high morbidity and mortality rates, mainly due to Graft versus host disease (GvHD). Recently, it has been demonstrated that the allogeneic immune response might be influenced...

2019-11-06 | MTBLS205 | MetaboLights
MetabolomicsMacrosteatosis Cause Graft Failure Via Proliferative Arrest in Rats after Liver Transplantation
We created a rat model with macrosteatosis (MaS) liver via methionine-cholinedeficient food (MCD) diet and transplanted the MaS liver into normal rats, then the rats without any MaS will be set as control. In the whole process of surgeries, we procured the liver tissue samples in different time poin...
2023-11-20 | MTBLS4163 | MetaboLights
MetabolomicsT cell metabolism during graft-versus-host disease(CAB 311)
Not available
ORGANISM(S): Mus musculus 
ST000181 | MetabolomicsWorkbench
MetabolomicsHost NLRP6 exacerbates graft-versus-host disease independent of microbial diversity
Not available
ORGANISM(S): Mus musculus 
ST001089 | MetabolomicsWorkbench
MetabolomicsT cell metabolism during graft-versus-host disease (CAB 307)-PART I
Not available
ORGANISM(S): Mus musculus 
ST000178 | MetabolomicsWorkbench
TranscriptomicsGene expression in the thymus medulla in the absence and presence of acute graft-versus-host disease
To investigate gene expression profile of medullary thymic epithelial cells with high surface density of MHC class II (mTEChigh), a murine parent into F1 hematopoietic stem cell transplantation model was administered. As recipient mice (B6xDBA/2)F1 (B6D2F1) were used that received either a syngeneic...
ORGANISM(S): Mus musculus 
2012-12-20 | E-MEXP-3745 | biostudies-arrayexpress
TranscriptomicsHigh weight differences between donor and recipient affect early kidney graft function -a role for IL-6 signaling
The frequency of delayed function of kidney transplants varies greatly and is associated with the quality of graft, donor age, and the duration of cold ischemia time. Body weight differences between donor and recipient can affect primary graft function. The underlying mechanism is poorly understood....
ORGANISM(S): Rattus norvegicus 
2010-04-08 | E-GEOD-15813 | biostudies-arrayexpress
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