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GenomicsEffect of Gsdmc knockdown in murine KPC cells transcriptome
Effect of Gsdmc knockdown in murine KPC cells transcriptome
PRJNA1051955 | ENA
GenomicsNur77 induces GSDMC-mediated pyroptosis
Nur77 induces GSDMC-mediated pyroptosis
PRJNA1141494 | ENA
TranscriptomicsEffect of Gsdmc knockdown in murine KPC cells transcriptome
We identified that Gsdmc gene is important for pancreatic cancer in tumorigenesis and metastasis. Here we used KPC mice (LSL-KrasG12D/+; p53f/f; Pdx1-Cre)-derived cancer cells, KPC cells in short, to check the effects of Gsdmc knockdown on primary tumor growth and metastasis. The results suggested t...
ORGANISM(S): Mus musculus 
2024-09-18 | GSE250062 | GEO
TranscriptomicsNur77 induces GSDMC-mediated pyroptosis
Pyroptosis is a type of lytic cell death executed by members of the gasdermin family. It has been demonstrated that induction of pyroptosis can effectively inhibit tumor growth, which implicates a new strategy for clinical tumor therapy, especially for those tumors (such as melanoma) that are insens...
ORGANISM(S): Homo sapiens 
2025-07-07 | GSE273365 | GEO
UnknownOverexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma.
Not available
S-EPMC6896373 | biostudies-literature
UnknownDisruption of heme homeostasis by nuclear receptor Nur77 induces pyroptosis through granzyme B-dependent GSDMC cleavage.
Not available
S-EPMC12711971 | biostudies-literature
UnknownThe metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8.
Not available
S-EPMC8410789 | biostudies-literature
UnknownMETTL14-upregulated miR-6858 triggers cell apoptosis in keratinocytes of oral lichen planus through decreasing GSDMC.
Not available
S-EPMC10517968 | biostudies-literature
UnknownN6-adenomethylation of GsdmC is essential for Lgr5+ stem cell survival to maintain normal colonic epithelial morphogenesis.
Not available
S-EPMC9398964 | biostudies-literature
ProteomicsIdentification of targets of DBIC
Pyroptosis is a type of lytic cell death executed by members of the gasdermin family. It has been demonstrated that induction of pyroptosis can effectively inhibit tumor growth, which implicates a new strategy for clinical tumor therapy, especially for those tumors (such as melanoma) that are insens...
ORGANISM(S): Homo sapiens (Human) 
2025-11-21 | PXD054435 | Pride
Nuclear receptor nur77  heme  granzyme b  gsdmc  pyroptosis 
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