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TranscriptomicsTotal RNA sequencing of INS-GFP+ cells differentiated from HES3 hESCs treated with DMSO or H1152
To systematically examine the cellular identity of INS+ cells derived after H1152 treatment, INSw/GFP HES3 hESCs were differentiated to a pancreatic progenitor population and treated with 10 µM H1152 for 8 days in sphere culture. The INS-GFP+ cells of H1152 or DMSO treated spheres were purified by c...
ORGANISM(S): Homo sapiens 
2017-07-01 | GSE84325 | GEO
ProteomicsTemporal analysis of phospho-proteome changes following Rho-kinase inhibition.
To define short and long-term changes in the phospho-proteome of the cells following Rho-kinase inhibition with H1152 inhibitor, in mouse embryonic fibroblast cells.
ORGANISM(S): Mus musculus (Mouse) 
2016-01-18 | PXD002515 | Pride
Mouse embryonic fibroblasts  rock1/2  phospho-myosin light chain  h1152 
GenomicsHomo sapiens
Total RNA sequencing of INS-GFP+ cells differentiated from HES3 hESCs treated with DMSO or H1152
PRJNA328860 | ENA
ProteomicsAnalysis of total proteome changes upon long-term treatment with Rho kinase inhibitor H1152.
We quantified protein changes associated with long-term Rho-kinase inhibition, using SILAC proteomics in conjugation with long-termH1152 treatment of mouse embryonic fibroblast cells.
ORGANISM(S): Mus musculus (Mouse) 
2016-01-18 | PXD002521 | Pride
Mouse embryonic fibroblasts  rock1/2  h1152  silac  cell cycle 
TranscriptomicsRNA-seq of coding RNAs from protrusions of MDA-MB231 cells treated with control or exosome core complex siRNA
MDA-MB-231 breast carcinoma cells were treated by non-targetting siRNA or siRNAs against EXOSC8. Subsequently, mRNAs from protrusions of the cells were quantified by RNA-seq in presence of Rho-kinase inhibitor H1152, using a filter based fractionation method.
ORGANISM(S): Homo sapiens 
2016-07-03 | E-MTAB-2548 | biostudies-arrayexpress
UnknownIn vivo Effects in Melanoma of ROCK Inhibition-Induced FasL Overexpression.
Not available
S-EPMC4500923 | biostudies-literature
TranscriptomicsExpression data from actomyosin contractility regulated genes
Actomyosin contractility regulates cell morphology and movement. The objective of this study was to identify whether actomyosin contractility regulates gene expression in tumour cells and whether such genes are involved in cell morphology and movement. Gene expression analysis was carried out on h...
ORGANISM(S): Homo sapiens 
2010-08-24 | E-GEOD-23764 | biostudies-arrayexpress
UnknownROCKII inhibition promotes the maturation of human pancreatic beta-like cells.
Not available
S-EPMC5563509 | biostudies-literature
TranscriptomicsExpression data from actomyosin contractility regulated genes
Actomyosin contractility regulates cell morphology and movement. The objective of this study was to identify whether actomyosin contractility regulates gene expression in tumour cells and whether such genes are involved in cell morphology and movement. Gene expression analysis was carried out on hig...
ORGANISM(S): Homo sapiens 
2010-08-24 | GSE23764 | GEO
UnknownRho kinase activity governs arteriolar myogenic depolarization.
Not available
S-EPMC5363734 | biostudies-literature
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