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Host recognition of pathogen-associated molecular patterns (PAMPs) initiates an innate immune response that is critical for pathogen elimination and engagement of adaptive immunity. Here we show that mammalian cells can detect and respond to the bacterial-derived monosaccharide heptose-1,7-bisphosph...
ORGANISM(S): Homo sapiens 
Effects of a novel HBP inhibitor, FR054, and Gemcitabine in pancreatic cancer cells
Host recognition of pathogen-associated molecular patterns (PAMPs) initiates an innate immune response that is critical for pathogen elimination and engagement of adaptive immunity. Here we show that mammalian cells can detect and respond to the bacterial-derived monosaccharide heptose-1,7-bisphosph...
ORGANISM(S): Homo sapiens 
2015-04-15 | GSE67840 | GEO
Complete genome of 2-hydroxybiphenyl degrader Pseudomonas azelaica HBP-1 and the associated mobile genetic elements.
In order to define the role of the Hexosamine Biosynthetic Pathaway (HBP) in pancreatic cancer cells proliferation, survival and gemcitabine resistance, we treated MiaPaCa2 and BxPC3 cells with FR054, a novel HBP inhbitor, and gemcitabine either alone or in combination for 48h
ORGANISM(S): Homo sapiens 
2023-05-08 | GSE223303 | GEO
Tumorigenesis is characterised by changes in transcriptional regulation and the androgen receptor (AR) has been identified as a key driver in prostate cancer. In this study, we show that the hexosamine biosynthetic pathway (HBP) genes are overexpressed in clinical prostate cancer and androgen-regula...
ORGANISM(S): Homo sapiens 
Gene expression data following heptose-bisphosphate (HBP) treatment of Jurkat T cells
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