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TranscriptomicsTranscription profiling of human hepatoma cells treated with 5-aza-dC, Trichostatin A, both, or control to elucidate the response to inhibition of DNA methylation and histone deacetylation
Expression profiling the response to inhibition of DNA methylation and histone deacetylation. Comparison of expression in HepG2 cells treated with 5-aza-dC, Trichostatin A, both, or none (control) to change methylation and acetylation status. Backgroubd: DNA methylation and histone deacetylation ar...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-5230 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling in camptothecin-treated or untreated hepatoma-derived exosomes
Totally 1,308 miRNAs were examined. Three miRNAs (hsa-miR-1976, 4728-3p, and 877-3p) were upregulated with fold change excess 0.8 and six miRNAs (hsa-miR-4497, -204-3p, -6126, -5787, -1273e, and -1908-3p) were downregulated in the exosome released from camptothecin-treated hepatoma. Comparing betwee...
ORGANISM(S): Homo sapiens 
2015-11-10 | E-GEOD-74829 | biostudies-arrayexpress
ProteomicsDataset for quantitative phospho-proteomics analysis of a serial hepatoma cell lines with increasing invasion and metastasis potential
Here, we used isobaric tags for relative and absolute quantitation (iTRAQ) based quantitative phospho-proteomics approach to identify biomarkers associated with hepatoma recurrence/metastasis in hepatoma cell lines with increasing metastasis ability.
ORGANISM(S): Homo Sapiens 
2019-09-25 | PXD015569 |
TranscriptomicsExpression profiling of hypoxic HepG2 hepatoma, U87 glioma, and MDA-MB231 breast cancer cells: time course
Analysis of expression changes of cultured HepG2 hepatoma, U87 glioma, and MDA-MB231 breast cancer cells subjected to hypoxia (0.5% O2) for 0, 4, 8, 12 hours . Results provide insight to cell type-specific response to hypoxia. HepG2 hepatoma, U87 glioma, and MDA-MB231 breast cancer cells were collec...
ORGANISM(S): Homo sapiens 
2010-06-21 | E-GEOD-18494 | biostudies-arrayexpress
TranscriptomicsMechanistic evaluation of the insulin response in H4IIE hepatoma cells: New endpoints for toxicity testing?
Transcriptional profiling of insulin exposed H4IIE cells at different time points (6h-24h) to 100 nM insulin, with untreated solvent control cells (blanks). The central role of hepatic insulin resistance in pandemic metabolic diseases urges investigation of the underlying mechanisms of its developme...
ORGANISM(S): Rattus norvegicus 
2012-06-17 | E-GEOD-35697 | biostudies-arrayexpress
ProteomicsPreparation of tirapazamine-resistant hepatoma cell line
The aim of the project was to obtain murine hepatoma MH22a [1] cell subline, resistant to anticancer agent 3-amino-1,2,4-benzotriazine-1,4-dioxide (tirapazamine, TPZ), and examine the changes of the protein expression as compared with parental cells, with the main emphasis on the changes of redox pr...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD039876 | Pride
Tirapazamine  hepatoma  resistance 
TranscriptomicsProfiling of promoter occupancy by PPARM-NM-1 in human hepatoma cells via ChIP-chip analysis
The transcription factor Peroxisome Proliferator-Activated Receptor M-NM-1 (PPARM-NM-1) is an important regulator of hepatic lipid metabolism. While PPARM-NM-1 is known to activate transcription of numerous genes, no comprehensive picture of PPARM-NM-1 binding to endogenous genes has yet been report...
ORGANISM(S): Homo sapiens 
2010-11-23 | E-GEOD-25547 | biostudies-arrayexpress
TranscriptomicsGene expression profiles for genetically engineered human hepatoma HepG2/8F_HS cells with or without heat treatment, cultured as monolayer or spheroids
We developed genetically engineered HepG2/8F_HS cells, in which eight liver-enriched transcription factor (LETF) genes—hepatocyte nuclear factor (HNF)-1α, HNF-1β, HNF-3β, HNF-4α, HNF-6, CCAAT/enhancer binding protein (C/EBP)-α, C/EBP-β and C/EBP-γ— under the control of TRE/PCMVmin promoter were intr...
ORGANISM(S): Homo sapiens 
2022-04-04 | E-MTAB-11486 | biostudies-arrayexpress
GenomicsExpression data from doxorubicin-resistant hepatoma cells
Expression data from doxorubicin-resistant hepatoma cells
PRJNA515485 | ENA
TranscriptomicsTranscription profiling of Con1 HCV human hepatoma cells
expression profiling of HCV infected human hepatoma cells
ORGANISM(S): Homo sapiens 
2010-12-31 | E-MEXP-2548 | biostudies-arrayexpress
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