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MetabolomicsMetabolite patterns between isogenic normal hiPSCs and Trisomy hiPSC
Not available
ORGANISM(S): Homo sapiens 
ST002281 | MetabolomicsWorkbench
TranscriptomicsComparing Control and Schizophrenic hiPSC-derived Neurons
Schizophrenia is a debilitating neurological disorder for which no cure exists. Few defining characteristics of schizophrenic neurons have been identified and the molecular mechanisms responsible for schizophrenia are not well understood, in part due to the lack of patient material for study. Human ...
ORGANISM(S): Homo sapiens 
2011-05-01 | E-GEOD-25673 | biostudies-arrayexpress
TranscriptomicsComparing isogenic pairs of hESC and hiPSC lines reveals genetic background and reprogramming method as primary sources of transcriptional variation
The equivalency of human induced pluripotent stem cells (hiPSCs) with human embryonic stem cells (hESCs) remains controversial. Here, we devised a strategy to assess the contribution of clonal growth, reprogramming method and genetic background to transcriptional patterns in hESCs and hiPSCs. Surpri...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-73211 | biostudies-arrayexpress
TranscriptomicsRNA-seq of hepatocytes obtained through step-wise differentiation of hIPSCs from a patient with A1AT deficiency and its point mutation-corrected isogenic hIPSC line. Comparison to primary hepatocytes from a healthy donor and an A1AT-deficient patient.
A1AT deficiency is an autosomal not recessive disorder caused by mutations in the SERPINA1 gene. Individuals with the Z variant retain polymerised protein in the endoplasmic reticulum of hepatocytes, predisposing them to liver disease. This study primarily aimed to uncover the molecular mechanisms t...
ORGANISM(S): Homo sapiens 
2018-06-26 | E-MTAB-6781 | biostudies-arrayexpress
ProteomicsContractile work contributes to maturation of energy metabolism in hiPSC-derived cardiomyocytes
Energy metabolism is a key aspect of cardiomyocyte biology. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are a promising tool for biomedical application, but they are immature and have not undergone metabolic shift related to early postnatal development. Cultivation of hiPSC...
ORGANISM(S): Homo sapiens (Human) 
2018-03-06 | PXD008205 | Pride
Human Ipsc Cardiomyocyte Engineered heart tissue 
TranscriptomicsExpression data from human induced pluripotent stem cells derived retinal pigment epithelium (hiPSC-RPE)
We generated hiPSCs from patients fibloblast with retinitis pigmentosa (RP) using retrovirus and Sendai virus vectors, which we differentiated into hiPSC derived retinal pigment epithelium using two different methods (SDIA and SFEB methods). We investigated whether these hiPSC-RPE colonies, which we...
ORGANISM(S): Homo sapiens 
2014-11-03 | E-GEOD-50738 | biostudies-arrayexpress
GenomicsHeterogeneity among hiPSC-MuPCs
Heterogeneity among hiPSC-MuPCs
PRJNA820042 | ENA
TranscriptomicsComparing Control and Schizophrenic hiPSC-derived NPCs
Cell-based models of many neurological and psychiatric diseases, established by reprogramming patient somatic cells into human induced pluripotent stem cells (hiPSCs), have now been reported. While numerous reports have demonstrated that neuronal cells differentiated from hiPSCs are electrophysiolo...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-40102 | biostudies-arrayexpress
TranscriptomicshiPSC-derived motor neurons: sporadic ALS patients vs. controls
Differentiated motor neurons from hiPSC derived from peripheral nerve fibroblasts of sporadic ALS patients and evaluated the gene expression profile by means microarray-linked to specific analysis tools. Two-condition experiment, ALS patients motor neurons vs. controls. Biological replicates: 3 ALS ...
ORGANISM(S): Homo sapiens 
2015-04-25 | E-GEOD-68240 | biostudies-arrayexpress
ProteomicsInvestigating hiPSC-CMs_DongLi
Proteomic analysis of hiPSC-CMs with drug treatment
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-01 | MSV000087351 | MassIVE
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