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ProteomicsThe regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome (part 1)
Despite the involvement of Poly(ADP-ribose) polymerase-1 (PARP1) in many important biological pathways, the target residues of PARP1-mediated ADP-ribosylation remain ambiguous. To explicate the ADP-ribosylation regulome, we analyze human cells depleted for key regulators of PARP1 activity, histone P...
ORGANISM(S): Homo sapiens (Human) 
2021-10-07 | PXD023835 | Pride
Parp1 Adpr Hpf1 Arh3 Par Parg Af1521 Mar Adp-ribosylation 
ProteomicsThe regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome (part 2)
Despite the involvement of Poly(ADP-ribose) polymerase-1 (PARP1) in many important biological pathways, the target residues of PARP1-mediated ADP-ribosylation remain ambiguous. To explicate the ADP-ribosylation regulome, we analyze human cells depleted for key regulators of PARP1 activity, histone P...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2021-10-11 | PXD027504 | Pride
Parp1 Adpr Hpf1 Arh3 Par Parg Af1521 Mar Adp-ribosylation 
ProteomicsSerine ADP-ribosylation depends on HPF1
We report that serine ADPr is strictly dependent on HPF1 (histone PARylation factor 1. Quantitative proteomics revealed that serine ADPr does not occur in cells lacking HPF1. We identified three endogenous serine ADPr sites are located on the PARP-1 automodification domain. Further identification of...
ORGANISM(S): Homo sapiens (Human) 
2017-02-10 | PXD005627 | Pride
Adp-ribosylation  hpf1  parp-1  parp-2  histones  proteomics 
ProteomicsHXMS on PARP1+DNA+HPF1 to study the dynamics of PARP1
The project is about studying the dynamics of PARP1 when bound to DNA and HPF1.
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026580 | Pride
Hxms Parp1 Hpf1 Dna 
UnknownSerine ADP-Ribosylation Depends on HPF1.
Not available
S-EPMC5344681 | biostudies-literature
UnknownDispensability of HPF1 for cellular removal of DNA single-strand breaks.
Not available
S-EPMC11472159 | biostudies-literature
UnknownHTS discovery of PARP1-HPF1 complex inhibitors in cancer.
Not available
S-EPMC10872402 | biostudies-literature
UnknownSlow Dissociation from the PARP1-HPF1 Complex Drives Inhibitor Potency.
Not available
S-EPMC10433523 | biostudies-literature
UnknownDual function of HPF1 in the modulation of PARP1 and PARP2 activities.
Not available
S-EPMC8566583 | biostudies-literature
UnknownHPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications.
Not available
S-EPMC8602370 | biostudies-literature
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