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MetabolomicsMass spectrometry imaging as an emerging tool for studying metabolism in human brain organoids

Human brain organoids are emerging models to study human brain development and pathology as they recapitulate the development and characteristics of major neural cell types, and enable manipulation through an in vitro system. Over the past decade, with the advent of spatial technologies,...

2023-05-23 | MTBLS7565 | MetaboLights
MetabolomicsMulti-level analysis of gut microbiome extracellular vesicles-host interaction reveals a connection to gut-brain axis signaling.

Microbiota-released extracellular vesicles (MEVs) have emerged as a key player in intercellular signaling. However, their involvement in the gut-brain axis has been poorly investigated. In this study, we aimed to investigate the cargo capacity of MEVs for bioactive metabolites and their interacti...

2025-08-12 | MTBLS8494 | MetaboLights
MetabolomicsBrain metabolomic profiling of eastern honey bee (Apis cerana) infested with the mite Varroa destructor
The mite Varroa destructor is currently the greatest threat to apiculture as it is causing a global decrease in honey bee colonies. However, it rarely causes serious damage to its native hosts, the eastern honey bees Apis cerana. To better understand the mechanism of resistance of A. cerana against ...
2017-10-27 | MTBLS379 | MetaboLights
MetabolomicsMonocolonization with Bacteroides thetaiotaomicron exerts region-specific effects on Alzheimer’s disease-related traits in the murine brain

Bacteroides thetaiotaomicron (B. theta) dominates the gut microbiome of most mammals. This strictly anaerobic gut symbiont colonizes the mucus layer of host intestinal epithelial cells in both healthy and diseased conditions. Reduced neuronal and vagal afferent innervation observed in ge...

2025-12-15 | MTBLS12896 | MetaboLights
MetabolomicsNeuroactive metabolites and bile acids are altered in extremely premature infants with brain injury

The gut microbiome has been associated with pathological neurophysiological evolvement in extremely premature infants suffering from brain injury. The exact underlying mechanism and its associated metabolic signatures in infants are not fully understood. To decipher metab...

2023-12-30 | MTBLS7560 | MetaboLights
MetabolomicsIntegrated Analysis of Gut Microbiota, Serum Metabolomics, and Proteomics Reveals Novel Associations With Clinical Symptoms in Patients With Cerebral Infarction
Cerebral infarction (CI) is a major cause of adult disability and mortality worldwide. Mounting evidence supports the critical role of the gut–brain axis in cerebrovascular disease progression. This study aimed to characterize the alterations in gut microbiota, serum metabolome, and serum proteome i...
2026-05-08 | MTBLS14356 | MetaboLights
ProteomicsCEGS Proteomics - A multiregional proteomic survey of the postnatal human brain
Here we exploit label-free quantitative tandem mass-spectrometry proteomics to create the first in-depth quantitative proteomic survey of regions of the postnatal human brain. We adopted a dual approach to analysing these human brain samples similar to that of a recent high-quality study of the mou...
ORGANISM(S): Homo sapiens (Human) 
2018-01-09 | PXD005445 | Pride
Human brain Regions Post natal development 
ProteomicsProtein Profile Changes in the Frontotemporal Lobes in Human Severe Traumatic Brain Injury
Severe traumatic brain injury (sTBI) is a serious public health issue with high morbidity and mortality rates. Previous proteomic studies on sTBI have mainly focused on human cerebrospinal fluid and serum, as well as on brain protein changes in murine models. However, human proteomic data in sTBI br...
ORGANISM(S): Homo sapiens (Human) 
2016-04-15 | PXD002783 | Pride
Severe traumatic brain injury  tmt (tandem mass tags)  human  proteomics 
ProteomicsInter-regional proteomic profiling of the human brain using optimized protein extraction method from formalin-fixed tissue to identify signaling pathways
Proteomics offers vast potential to study the molecular regulation of the human brain. Formalin fixation is a common method for preserving human tissue, however, presents challenges for proteomic analysis. In this study we compared the efficiency of two different protein extraction buffers on three ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-22 | PXD039808 | Pride
Formalin-fixed Proteomics Brain Mass spectrometry Pathways Protein Region Method Human Signaling 
TranscriptomicsmRNA-Seq expression and MS3 proteomics profiling of human post-mortem BA9 brain tissue for Parkinson Disease and neurologically normal individuals
Parkinson disease (PD) is a neurodegenerative disease characterized by the accumulation of alpha-synuclein (SNCA) and other proteins in aggregates termed “Lewy Bodies” within neurons. PD has both genetic and environmental risk factors, and while processes leading to aberrant protein aggregation ...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-68719 | biostudies-arrayexpress
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